Human CFB Recombinant Protein – Cat# MBS147192

Complement Factor B (CFB) Human Recombinant Protein

Name: CFB Recombinant Protein; Complement Factor B; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147192
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147192

Description: CFB Human Recombinant produced in Sf9 Baculovirus cells isa single, glycosylated polypeptide chain containing 245 amino acids (26-259a.a.)and having a molecular mass of 27.3kDa (Molecular size on SDS-PAGE will appearat approximately 28-40 kDa).… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Complement Factor B (CFB), Recombinant Protein

Full Product Name

Recombinant Human Complement Factor B, Sf9

Product Gene Name

CFB recombinant protein

Product Synonym Names

CFB; AHUS4; ARMD14; BF; BFD; CFAB; CFBD; FB; FBI12; GBG; H2-Bf; PBF2; Complement Factor B; B-Factor; Properdin; Properdin Factor B; C3/C5 Convertase; EC 3.4.21.47; PBF2; Glycine-Rich Beta-Glycoprotein; Glycine-Rich Beta Glycoprotein; C3 Proaccelerator; C3 Proactivator; EC 3.4.2; FBI12; H2-Bf; CFB Human, Sf9; Complement Factor B Human Recombinant, Sf9

Sequence

ADPEF TPWSLARPQG SCSLE GVEIKGGSFR LLQEGQALEY VCPSGFYPYP VQTRTCRSTG SWSTLKTQDQ KTVRKAECRA IHCPRPHDFE NGEYWPRSPY YNVSDEISFH CYDGYTLRGS ANRTCQVNGR WSGQTAICDN GAGYCSNPGI PIGTRKVGSQ YRLEDSVTYH CSRGLTLRGS QRRTCQEGGS WSGTEPSCQD SFMYDTPQEV AEAFLSSLTE TIEGVDAEDG HGPGEQQKRH HHHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution
Protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles

Molecular Weight

68,872 Da

OMIM

X72875 mRNA

3D Structure

ModBase 3D Structure for P00751

Product Categories/Family for CFB recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Complement Component; CFB Human; Sf9

Other Notes

Small volumes of CFB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CFB purchase

MBS147192 is a recombinant protein targeting CFB. Also known as Recombinant Human Complement Factor B, Sf9. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CFB. It may not necessarily be applicable to this product.

NCBI GI #

584908

NCBI GeneID

629

NCBI Accession #

P00751.2

UniProt Primary Accession #

P00751

UniProt Secondary Accession #

O15006; Q29944; Q53F89; Q5JP67; Q5ST50; Q96HX6; Q9BTF5; Q9BX92; B0QZQ6

UniProt Related Accession #

P00751

NCBI Official Full Name

Complement factor B

NCBI Official Synonym Full Names

complement factor B

NCBI Official Symbol

CFB

NCBI Official Synonym Symbols

BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14

UniProt Protein Name

Complement factor B

UniProt Synonym Protein Names

C3/C5 convertase; Glycine-rich beta glycoprotein; GBG

Protein Family

Complement factor

UniProt Gene Name

CFB

UniProt Synonym Gene Names

BF; BFD; GBG

NCBI Protein Information

complement factor B

NCBI Summary for CFB

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]

UniProt Comments for CFB

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Research Articles on CFB

1. The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CFB recombinant protein

Reference Product	PubMed Publications
CFI recombinant protein	>30 publications with CFB and CFI
SERPING1 recombinant protein	>6 publications with CFB and SERPING1
C1R recombinant protein	>3 publications with CFB and C1R
CFP recombinant protein	>3 publications with CFB and CFP
C4A recombinant protein	>1 publications with CFB and C4A

Pathways associated with CFB recombinant protein

Products by Pathway	Pathway Diagram
Activation Of C3 And C5 Pathway antibodies	Activation Of C3 And C5 Pathway Diagram
Alternative Complement Activation Pathway antibodies	Alternative Complement Activation Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Regulation Of Complement Cascade Pathway antibodies	Regulation Of Complement Cascade Pathway Diagram
Staphylococcus Aureus Infection Pathway antibodies	Staphylococcus Aureus Infection Pathway Diagram

Diseases associated with CFB recombinant protein

Disease Name	Pubmed Publications
Macular Degeneration Antibodies	>78 publications with CFB and Macular Degeneration
Cardiovascular Diseases Antibodies	>23 publications with CFB and Cardiovascular Diseases
Inflammation Antibodies	>21 publications with CFB and Inflammation
Immune System Diseases Antibodies	>19 publications with CFB and Immune System Diseases
Necrosis Antibodies	>15 publications with CFB and Necrosis
Nervous System Diseases Antibodies	>15 publications with CFB and Nervous System Diseases
Atypical Hemolytic Uremic Syndrome Antibodies	>15 publications with CFB and Atypical Hemolytic Uremic Syndrome
Kidney Diseases Antibodies	>14 publications with CFB and Kidney Diseases
Fibrosis Antibodies	>14 publications with CFB and Fibrosis
Heart Diseases Antibodies	>11 publications with CFB and Heart Diseases

Organs/Tissues associated with CFB recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>78 publications with CFB and Blood
Eye Antibodies	>60 publications with CFB and Eye
Heart Antibodies	>36 publications with CFB and Heart
Muscle Antibodies	>30 publications with CFB and Muscle
Liver Antibodies	>24 publications with CFB and Liver
Intestine Antibodies	>15 publications with CFB and Intestine
Kidney Antibodies	>15 publications with CFB and Kidney
Bone Antibodies	>12 publications with CFB and Bone
Brain Antibodies	>9 publications with CFB and Brain
Lung Antibodies	>8 publications with CFB and Lung