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CD3G Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147201

Description: CD3G Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 103 amino acids (23-116 a.a.) and having a molecular mass of 11.8kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).… More details

$250 / 0.001 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD3G, Recombinant Protein
Full Product Name
Recombinant Human CD3G
Product Gene Name
CD3G recombinant protein
Product Synonym Names
T-cell surface glycoprotein CD3 gamma chain; CD3-GAMMA; T3G; CD3G; CD3G Human; CD3G Human Recombinant
Sequence
ADP QSIKGNH LVKVYDYQED GSVLLTCDAE AKNITWFKDG KMIGFLTEDK KKWNLGSNAK DPRGMYQCKG SQNKSKPLQV YYRMCQNCIE LNAATISHHH HHH.
Host
Sf9, Insect cells
Form/Format
Sterile filtered clear solution
Protein solution (0.5mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Molecular Weight
20,469 Da
OMIM
X04145 mRNA
3D Structure
ModBase 3D Structure for P09693

Product Categories/Family for CD3G recombinant protein

Recombinant & Natural Proteins; CD Antigens; CD3; CD3G Human

Other Notes

Small volumes of CD3G recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD3G purchase

MBS147201 is a recombinant protein targeting CD3G. Also known as Recombinant Human CD3G. Host: Sf9, Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD3G. It may not necessarily be applicable to this product.

NCBI GI #
115993
NCBI GeneID
917
NCBI Accession #
P09693.1
UniProt Primary Accession #
P09693
UniProt Secondary Accession #
Q2HIZ6
UniProt Related Accession #
P09693
NCBI Official Full Name
T-cell surface glycoprotein CD3 gamma chain
NCBI Official Synonym Full Names
CD3g molecule
NCBI Official Symbol
CD3G
NCBI Official Synonym Symbols
T3G; IMD17; CD3-GAMMA
UniProt Protein Name
T-cell surface glycoprotein CD3 gamma chain
UniProt Synonym Protein Names
T-cell receptor T3 gamma chain; CD_antigen: CD3g
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD3G
UniProt Synonym Gene Names
T3G
NCBI Protein Information
T-cell surface glycoprotein CD3 gamma chain

NCBI Summary for CD3G

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD3G

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
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Research Articles on CD3G

1. CD3 showed a positive correlation with tryptase and microvascular density, while multiple regression analysis efficaciously predicted microvascular density depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in Diffuse large B cell lymphoma patients.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CD3G recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram

Diseases associated with CD3G recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4 publications with CD3G and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with CD3G and Inflammation
 Heart Diseases Antibodies  >2 publications with CD3G and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with CD3G and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >1 publications with CD3G and Disease Models, Animal
 Liver Neoplasms Antibodies  >1 publications with CD3G and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with CD3G and Neoplasms, Experimental
 Kidney Diseases Antibodies  >1 publications with CD3G and Kidney Diseases

Organs/Tissues associated with CD3G recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with CD3G and Blood
 Thymus Antibodies  >3 publications with CD3G and Thymus
 Testis Antibodies  >1 publications with CD3G and Testis
 Brain Antibodies  >1 publications with CD3G and Brain
 Spleen Antibodies  >1 publications with CD3G and Spleen
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