Human SRSF1 Recombinant Protein – Cat# MBS147206

Serine/Arginine-Rich Splicing Factor 1 (SRSF1) Human Recombinant Protein

Name: SRSF1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147206
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147206

Description: SRSF1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 254 amino acids (1-248) and having a molecular mass of 28.5kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Serine/arginine-Rich Splicing Factor 1 (SRSF1), Recombinant Protein

Full Product Name

Recombinant Human Serine/arginine-Rich Splicing Factor 1, Sf9

Product Gene Name

SRSF1 recombinant protein

Product Synonym Names

SRSF1; ASF; SF2; SF2p33; SFRS1; Splicing Factor; Arginine/Serine-Rich; 30-KD; A; Alternate Splicing Factor; SRp30a; ASF-1; Serine And Arginine Rich Splicing Factor 1; Pre-MRNA-Splicing Factor SF2; P33 Subunit; Splicing Factor; Arginine/Serine-Rich 1; Serine/Arginine-Rich Splicing Factor 1; Alternative-Splicing Factor 1; SR Splicing Factor 1; Splicing Factor 2; SRSF1 Human, Sf9; Serine/arginine-Rich Splicing Factor 1 Human Recombinant, Sf9

Sequence

MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG GGGGGGAPRG RYGPPSRRSE NRVVVSGLPP SGSWQDLKDH MREAGDVCYA DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF RSHEGETAYI RVKVDGPRSP SYGRSRSRSR SRSRSRSRSN SRSRSYSPRR SRGSPRYSPR HSRSRSRTHH HHHH.

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution
SRSF1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 100mM KCl, 1mM DTT, 0.2mM EDTA and 40% Glycerol

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles

Molecular Weight

22,460 Da

OMIM

M72709 mRNA

3D Structure

ModBase 3D Structure for Q07955

Product Categories/Family for SRSF1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Other; SRSF1 Human; Sf9

Other Notes

Small volumes of SRSF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SRSF1 purchase

MBS147206 is a recombinant protein targeting SRSF1. Also known as Recombinant Human Serine/arginine-Rich Splicing Factor 1, Sf9. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for SRSF1. It may not necessarily be applicable to this product.

NCBI GI #

730773

NCBI GeneID

6426

NCBI Accession #

Q07955.2

UniProt Primary Accession #

Q07955

UniProt Secondary Accession #

Q13809; B2R6Z7; D3DTZ3

UniProt Related Accession #

Q07955

NCBI Official Full Name

Serine/arginine-rich splicing factor 1

NCBI Official Synonym Full Names

serine and arginine rich splicing factor 1

NCBI Official Symbol

SRSF1

NCBI Official Synonym Symbols

ASF; SF2; SFRS1; SF2p33; SRp30a

UniProt Protein Name

Serine/arginine-rich splicing factor 1

UniProt Synonym Protein Names

Alternative-splicing factor 1; ASF-1; Splicing factor, arginine/serine-rich 1; pre-mRNA-splicing factor SF2, P33 subunit

Protein Family

Serine/arginine-rich splicing factor

UniProt Gene Name

SRSF1

UniProt Synonym Gene Names

ASF; SF2; SF2P33; SFRS1; ASF-1

NCBI Protein Information

serine/arginine-rich splicing factor 1

NCBI Summary for SRSF1

This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]

UniProt Comments for SRSF1

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

Research Articles on SRSF1

1. Immune suppression of JC virus gene expression is mediated by SRSF1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SRSF1 recombinant protein

Reference Product	PubMed Publications
SRPK1 recombinant protein	>15 publications with SRSF1 and SRPK1
SRSF2 recombinant protein	>11 publications with SRSF1 and SRSF2
SRSF4 recombinant protein	>2 publications with SRSF1 and SRSF4
U2AF1 recombinant protein	>1 publications with SRSF1 and U2AF1

Pathways associated with SRSF1 recombinant protein

Products by Pathway	Pathway Diagram
Cleavage Of Growing Transcript In The Termination Region Pathway antibodies	Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies	Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
RNA Polymerase II Transcription Pathway antibodies	RNA Polymerase II Transcription Pathway Diagram
RNA Polymerase II Transcription Termination Pathway antibodies	RNA Polymerase II Transcription Termination Pathway Diagram
Spliceosome Pathway antibodies	Spliceosome Pathway Diagram
Spliceosome Pathway antibodies	Spliceosome Pathway Diagram
Transport Of Mature Transcript To Cytoplasm Pathway antibodies	Transport Of Mature Transcript To Cytoplasm Pathway Diagram

Diseases associated with SRSF1 recombinant protein

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>8 publications with SRSF1 and Lung Neoplasms
Liver Neoplasms Antibodies	>3 publications with SRSF1 and Liver Neoplasms
Breast Neoplasms Antibodies	>3 publications with SRSF1 and Breast Neoplasms
Kidney Diseases Antibodies	>3 publications with SRSF1 and Kidney Diseases
Liver Diseases Antibodies	>3 publications with SRSF1 and Liver Diseases
Inflammation Antibodies	>2 publications with SRSF1 and Inflammation
Carcinoma, Hepatocellular Antibodies	>2 publications with SRSF1 and Carcinoma, Hepatocellular
Disease Models, Animal Antibodies	>2 publications with SRSF1 and Disease Models, Animal
Nervous System Diseases Antibodies	>2 publications with SRSF1 and Nervous System Diseases
Atrophy Antibodies	>2 publications with SRSF1 and Atrophy

Organs/Tissues associated with SRSF1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>10 publications with SRSF1 and Lung
Vascular Antibodies	>10 publications with SRSF1 and Vascular
Blood Antibodies	>7 publications with SRSF1 and Blood
Heart Antibodies	>6 publications with SRSF1 and Heart
Liver Antibodies	>5 publications with SRSF1 and Liver
Brain Antibodies	>4 publications with SRSF1 and Brain
Nerve Antibodies	>3 publications with SRSF1 and Nerve
Kidney Antibodies	>2 publications with SRSF1 and Kidney
Ovary Antibodies	>2 publications with SRSF1 and Ovary
Eye Antibodies	>2 publications with SRSF1 and Eye