Human DPH2 Recombinant Protein – Cat# MBS147210

Diphthamide Biosynthesis 2 (DPH2) Human Recombinant Protein

Name: DPH2 Recombinant Protein; Diphthamide Biosynthesis 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147210
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147210

Description: DPH2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 497 amino acids (1-489a.a.) and having a molecular mass of 53.1kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Diphthamide Biosynthesis 2 (DPH2), Recombinant Protein

Full Product Name

Recombinant Human Diphthamide Biosynthesis 2

Product Gene Name

DPH2 recombinant protein

Product Synonym Names

DPH2 Homolog; S-Adenosyl-L-Methionine:L-Histidine 3-Amino-3-Carboxypropyltransferase 2; Diphtheria Toxin Resistance Protein 2; Diphthamide Biosynthesis Protein 2; DPH2L2; Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis-Like 2; 2-(3-Amino-3-Carboxypropyl)Histidine Synthase Subunit 2; Diphthamide Biosynthesis Protein 2 Homolog-Like 2; Diphthamide Biosynthesis-Like Protein 2; EC 2.5.1.108; DPH2-Like 2; DPH2; DPH2 Human; Diphthamide Biosynthesis 2 Human Recombinant

Sequence

MESMFSSPAE AALQRETGVP GLLTPLPDLD GVYELERVAG FVRDLGCERV ALQFPDQLLG DAVAVAARLE ETTGSKMFIL GDTAYGSCCV DVLGAEQAGA QALIHFGPAC LSPPARPLPV AFVLRQRSVA LELCVKAFEA QNPDPKAPVV LLSEPACAHA LEALATLLRP RYLDLLVSSP AFPQPVGSLS PEPMPLERFG RRFPLAPGRR LEEYGAFYVG GSKASPDPDL DPDLSRLLLG WAPGQPFSSC CPDTGKTQDE GARAGRLRAR RRYLVERARD ARVVGLLAGT LGVAQHREAL AHLRNLTQAA GKRSYVLALG RPTPAKLANF PEVDVFVLLA CPLGALAPQL SGSFFQPILA PCELEAACNP AWPPPGLAPH LTHYADLLPG SPFHVALPPP ESELWETPDV SLITGDLRPP PAWKSSNDHG SLALTPRPQL ELAESSPAAS FLSSRSWQGL EPRLGQTPVT EAVSGRRGIA IAYEDEGSGL EHHHHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution
Protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4), 1mM DTT and 20% glycerol

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles

Molecular Weight

38,510 Da

OMIM

AF053003 mRNA

3D Structure

ModBase 3D Structure for Q9BQC3

Product Categories/Family for DPH2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Other; DPH2 Human

Other Notes

Small volumes of DPH2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DPH2 purchase

MBS147210 is a recombinant protein targeting DPH2. Also known as Recombinant Human Diphthamide Biosynthesis 2. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for DPH2. It may not necessarily be applicable to this product.

NCBI GI #

74761201

NCBI GeneID

1802

NCBI Accession #

Q9BQC3.1

UniProt Primary Accession #

Q9BQC3

UniProt Secondary Accession #

O60623; A8MVC9; B2RDE3; B4DNI8

UniProt Related Accession #

Q9BQC3

NCBI Official Full Name

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

NCBI Official Synonym Full Names

DPH2 homolog

NCBI Official Symbol

DPH2

NCBI Official Synonym Symbols

DPH2L2

UniProt Protein Name

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

UniProt Synonym Protein Names

Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2Curated; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2Curated

Protein Family

2-(3-amino-3-carboxypropyl)histidine synthase

UniProt Gene Name

DPH2

UniProt Synonym Gene Names

DPH2L2

NCBI Protein Information

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; diphthamide biosynthesis protein 2

NCBI Summary for DPH2

This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

UniProt Comments for DPH2

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Research Articles on DPH2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with DPH2 recombinant protein

Products by Pathway	Pathway Diagram
Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies	Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Synthesis Of Diphthamide-EEF2 Pathway antibodies	Synthesis Of Diphthamide-EEF2 Pathway Diagram

Diseases associated with DPH2 recombinant protein

Disease Name	Pubmed Publications
Ovarian Neoplasms Antibodies	>2 publications with DPH2 and Ovarian Neoplasms
Nervous System Diseases Antibodies	>1 publications with DPH2 and Nervous System Diseases
Breast Neoplasms Antibodies	>1 publications with DPH2 and Breast Neoplasms
Liver Diseases Antibodies	>1 publications with DPH2 and Liver Diseases
Poisoning Antibodies	>1 publications with DPH2 and Poisoning
Necrosis Antibodies	>1 publications with DPH2 and Necrosis

Organs/Tissues associated with DPH2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Ovary Antibodies	>2 publications with DPH2 and Ovary
Uterus Antibodies	>1 publications with DPH2 and Uterus
Liver Antibodies	>1 publications with DPH2 and Liver
Blood Antibodies	>1 publications with DPH2 and Blood
Eye Antibodies	>1 publications with DPH2 and Eye
Brain Antibodies	>1 publications with DPH2 and Brain