Human SIGLEC5 Recombinant Protein – Cat# MBS147221

Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Human Recombinant Protein

Name: SIGLEC5 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147221
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147221

Description: SIGLEC5 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 667 amino acids (17-441a.a.) and having a molecular mass of 74.2kDa (Molecular size on SDS-PAGE will appear at approximately… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5), Recombinant Protein

Full Product Name

Recombinant Human Sialic Acid Binding Ig Like Lectin 5

Product Gene Name

SIGLEC5 recombinant protein

Product Synonym Names

Sialic Acid Binding Ig Like Lectin 5; Obesity-Binding Protein 2; OB-Binding Protein 2; CD33 Antigen-Like 2; SIGLEC-5; CD33L2; OB-BP2; OBBP2; Sialic Acid-Binding Immunoglobulin-Like Lectin 5; Sialic Acid Binding Ig-Like Lectin 5; Sialic Acid-Binding Ig-Like Lectin 5; CD170 Antigen; CD170; Sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD170; SIGLEC5 Human; Sialic Acid Binding Ig Like Lectin 5 Human Recombinant

Sequence

ADL EKPVYEL QVQKSVTVQE GLCVLVPCSF SYPWRSWYSS PPLYVYWFRD GEIPYYAEVV ATNNPDRRVK PETQGRFRLL GDVQKKNCSL SIGDARMEDT GSYFFRVERG RDVKYSYQQN KLNLEVTALI EKPDIHFLEP LESGRPTRLS CSLPGSCEAG PPLTFSWTGN ALSPLDPETT RSSELTLTPR PEDHGTNLTC QMKRQGAQVT TERTVQLNVS YAPQTITIFR NGIALEILQN TSYLPVLEGQ ALRLLCDAPS NPPAHLSWFQ GSPALNATPI SNTGILELRR VRSAEEGGFT CRAQHPLGFL QIFLNLSVYS LPQLLGPSCS WEAEGLHCRC SFRARPAPSL CWRLEEKPLE GNSSQGSFKV NSSSAGPWAN SSLILHGGLS SDLKVSCKAW NIYGSQSGSV LLLQGRSNLG TGVVPAALLE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution
Protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4)

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles

Molecular Weight

60,715 Da

OMIM

AF170484 mRNA

3D Structure

ModBase 3D Structure for O15389

Product Categories/Family for SIGLEC5 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; SIGLEC; SIGLEC5 Human

Other Notes

Small volumes of SIGLEC5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIGLEC5 purchase

MBS147221 is a recombinant protein targeting SIGLEC5. Also known as Recombinant Human Sialic Acid Binding Ig Like Lectin 5. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for SIGLEC5. It may not necessarily be applicable to this product.

NCBI GI #

25009254

NCBI GeneID

8778

NCBI Accession #

O15389.1

UniProt Primary Accession #

O15389

UniProt Related Accession #

O15389

NCBI Official Full Name

Sialic acid-binding Ig-like lectin 5

NCBI Official Synonym Full Names

sialic acid binding Ig like lectin 5

NCBI Official Symbol

SIGLEC5

NCBI Official Synonym Symbols

CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5

UniProt Protein Name

Sialic acid-binding Ig-like lectin 5

UniProt Synonym Protein Names

CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD_antigen: CD170

Protein Family

Sialic acid-binding Ig-like lectin

UniProt Gene Name

SIGLEC5

UniProt Synonym Gene Names

CD33L2; OBBP2; Siglec-5; OB-BP2; OB-binding protein 2

NCBI Protein Information

sialic acid-binding Ig-like lectin 5

NCBI Summary for SIGLEC5

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]

UniProt Comments for SIGLEC5

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Research Articles on SIGLEC5

1. An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SIGLEC5 recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with SIGLEC5 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>19 publications with SIGLEC5 and Inflammation
Asthma Antibodies	>13 publications with SIGLEC5 and Asthma
Lung Diseases Antibodies	>10 publications with SIGLEC5 and Lung Diseases
Respiratory Hypersensitivity Antibodies	>7 publications with SIGLEC5 and Respiratory Hypersensitivity
Disease Models, Animal Antibodies	>7 publications with SIGLEC5 and Disease Models, Animal
Necrosis Antibodies	>4 publications with SIGLEC5 and Necrosis
Fibrosis Antibodies	>3 publications with SIGLEC5 and Fibrosis
Pneumonia Antibodies	>3 publications with SIGLEC5 and Pneumonia
Hepatitis Antibodies	>2 publications with SIGLEC5 and Hepatitis
Prostatic Diseases Antibodies	>1 publications with SIGLEC5 and Prostatic Diseases

Organs/Tissues associated with SIGLEC5 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>44 publications with SIGLEC5 and Blood
Lung Antibodies	>14 publications with SIGLEC5 and Lung
Bone Antibodies	>10 publications with SIGLEC5 and Bone
Bone Marrow Antibodies	>10 publications with SIGLEC5 and Bone Marrow
Spleen Antibodies	>4 publications with SIGLEC5 and Spleen
Kidney Antibodies	>3 publications with SIGLEC5 and Kidney
Intestine Antibodies	>2 publications with SIGLEC5 and Intestine
Lymph Node Antibodies	>1 publications with SIGLEC5 and Lymph Node
Thymus Antibodies	>1 publications with SIGLEC5 and Thymus
Brain Antibodies	>1 publications with SIGLEC5 and Brain