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L1 Cell Adhesion Molecule (L1CAM) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147235

Description: L1CAM Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 1104 amino acids (20-1115a.a.) and having a molecular mass of 123.6kDa (Molecular size on SDS-PAGE will appear at approximately… More details

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Product Overview

Online Datasheet in PDF
Product Name
L1 Cell Adhesion Molecule (L1CAM), Recombinant Protein
Full Product Name
Recombinant Human L1 Cell Adhesion Molecule
Product Gene Name
L1CAM recombinant protein
Product Synonym Names
L1 Cell Adhesion Molecule; Antigen Identified By Monoclonal Antibody R1; N-CAM-L1; NCAM-L1; CAML1; MIC5; Neural Cell Adhesion Molecule L1; CD171 Antigen; N-CAML1; CD171; HSAS1; MASA; HSAS; SPG1; S10; L1CAM Human; L1 Cell Adhesion Molecule Human Recombinant
Sequence
IQIPEELMEP PVITEQSPRR LVVFPTDDIS LKCEASGKPE VQFRWTRDGV HFKPKEELGV TVYQSPHSGS FTITGNNSNF AQRFQGIYRC FASNKLGTAM SHEIRLMAEG APKWPKETVK PVEVEEGESV VLPCNPPPSA EPLRIYWMNS KILHIKQDER VTMGQNGNLY FANVLTSDNH SDYICHAHFP GTRTIIQKEP IDLRVKATNS MIDRKPRLLF PTNSSSHLVA LQGQPLVLEC IAEGFPTPTI KWLRPSGPMP ADRVTYQNHN KTLQLLKVGE EDDGEYRCLA ENSLGSARHA YYVTVEAAPY WLHKPQSHLY GPGETARLDC QVQGRPQPEV TWRINGIPVE ELAKDQKYRI QRGALILSNV QPSDTMVTQC EARNRHGLLL ANAYIYVVQL PAKILTADNQ TYMAVQGSTA YLLCKAFGAP VPSVQWLDED GTTVLQDERF FPYANGTLGI RDLQANDTGR YFCLAANDQN NVTIMANLKV KDATQITQGP RSTIEKKGSR VTFTCQASFD PSLQPSITWR GDGRDLQELG DSDKYFIEDG RLVIHSLDYS DQGNYSCVAS TELDVVESRA QLLVVGSPGP VPRLVLSDLH LLTQSQVRVS WSPAEDHNAP IEKYDIEFED KEMAPEKWYS LGKVPGNQTS TTLKLSPYVH YTFRVTAINK YGPGEPSPVS ETVVTPEAAP EKNPVDVKGE GNETTNMVIT WKPLRWMDWN APQVQYRVQW RPQGTRGPWQ EQIVSDPFLV VSNTSTFVPY EIKVQAVNSQ GKGPEPQVTI GYSGEDYPQA IPELEGIEIL NSSAVLVKWR PVDLAQVKGH LRGYNVTYWR EGSQRKHSKR HIHKDHVVVP ANTTSVILSG LRPYSSYHLE VQAFNGRGSG PASEFTFSTP EGVPGHPEAL HLECQSNTSL LLRWQPPLSH NGVLTGYVLS YHPLDEGGKG QLSFNLRDPE LRTHNLTDLS PHLRYRFQLQ ATTKEGPGEA IVREGGTMAL SGISDFGNIS ATAGENYSVV SWVPKEGQCN FRFHILFKAL GEEKGGASLS PQYVSYNQSS YTQWDLQPDT DYEIHLFKER MFRHQMAVKT NGTGRVRLPP AGFATELEHH HHHH.
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered colorless solution
Protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Molecular Weight
138,908 Da
OMIM
X59847 mRNA
3D Structure
ModBase 3D Structure for P32004

Product Categories/Family for L1CAM recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Intercellular Adhesion Molecule; L1CAM Human

Other Notes

Small volumes of L1CAM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L1CAM purchase

MBS147235 is a recombinant protein targeting L1CAM. Also known as Recombinant Human L1 Cell Adhesion Molecule. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for L1CAM. It may not necessarily be applicable to this product.

NCBI GI #
1705571
NCBI GeneID
3897
NCBI Accession #
P32004.2
UniProt Primary Accession #
P32004
UniProt Secondary Accession #
Q8TA87; A0AV65; A4ZYW4; B2RMU7; G3XAF4
UniProt Related Accession #
P32004
NCBI Official Full Name
Neural cell adhesion molecule L1
NCBI Official Synonym Full Names
L1 cell adhesion molecule
NCBI Official Symbol
L1CAM
NCBI Official Synonym Symbols
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
UniProt Protein Name
Neural cell adhesion molecule L1
UniProt Synonym Protein Names
CD_antigen: CD171
Protein Family
Neural cell adhesion molecule
UniProt Gene Name
L1CAM
UniProt Synonym Gene Names
CAML1; MIC5; N-CAM-L1; NCAM-L1
NCBI Protein Information
neural cell adhesion molecule L1

NCBI Summary for L1CAM

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
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UniProt Comments for L1CAM

Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
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Research Articles on L1CAM

1. L1CAM may have a role in human endometrial cancer and miR-34a has an inverse role to L1CAMEXP

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with L1CAM recombinant protein

 Reference Product  PubMed Publications
 ANK2 recombinant protein  >8 publications with L1CAM and ANK2
 ATL1 recombinant protein  >2 publications with L1CAM and ATL1
 ANK3 recombinant protein  >1 publications with L1CAM and ANK3
 ANK1 recombinant protein  >1 publications with L1CAM and ANK1

Pathways associated with L1CAM recombinant protein

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram

Diseases associated with L1CAM recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >356 publications with L1CAM and Nervous System Diseases
 Brain Diseases Antibodies  >232 publications with L1CAM and Brain Diseases
 Disease Models, Animal Antibodies  >85 publications with L1CAM and Disease Models, Animal
 Adenocarcinoma Antibodies  >56 publications with L1CAM and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >42 publications with L1CAM and Ovarian Neoplasms
 Peripheral Nervous System Diseases Antibodies  >27 publications with L1CAM and Peripheral Nervous System Diseases
 Movement Disorders Antibodies  >26 publications with L1CAM and Movement Disorders
 Neoplasms, Experimental Antibodies  >26 publications with L1CAM and Neoplasms, Experimental
 Aphasia Antibodies  >26 publications with L1CAM and Aphasia
 Nerve Degeneration Antibodies  >24 publications with L1CAM and Nerve Degeneration

Organs/Tissues associated with L1CAM recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >869 publications with L1CAM and Brain
 Nerve Antibodies  >476 publications with L1CAM and Nerve
 Embryonic Tissue Antibodies  >112 publications with L1CAM and Embryonic Tissue
 Ganglia Antibodies  >68 publications with L1CAM and Ganglia
 Eye Antibodies  >61 publications with L1CAM and Eye
 Muscle Antibodies  >49 publications with L1CAM and Muscle
 Kidney Antibodies  >41 publications with L1CAM and Kidney
 Skin Antibodies  >35 publications with L1CAM and Skin
 Lung Antibodies  >33 publications with L1CAM and Lung
 Liver Antibodies  >32 publications with L1CAM and Liver
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