Human CDH2 Recombinant Protein – Cat# MBS147244

Cadherin 2 (CDH2) Human Recombinant Protein

Name: CDH2 Recombinant Protein; Cadherin 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147244
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147244

Description: CDH2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 574 amino acids (160-724a.a.) and having a molecular mass of 62.9kDa (Molecular size on SDS-PAGE will appear at approximately… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cadherin 2 (CDH2), Recombinant Protein

Full Product Name

Recombinant Human Cadherin 2

Product Gene Name

CDH2 recombinant protein

Product Synonym Names

Cadherin 2; Cadherin 2; Type 1; N-Cadherin (Neuronal); Neural Cadherin; N-Cadherin; CDw325; NCAD; CDHN; Calcium-Dependent Adhesion Protein; Neuronal; CD325 Antigen; N-Cadherin 1; Cadherin-2; CD325; CDH2 Human; Cadherin 2 Human Recombinant

Sequence

ADP DWVIPPI NLPENSRGPF PQELVRIRSD RDKNLSLRYS VTGPGADQPP TGIFIINPIS GQLSVTKPLD REQIARFHLR AHAVDINGNQ VENPIDIVIN VIDMNDNRPE FLHQVWNGTV PEGSKPGTYV MTVTAIDADD PNALNGMLRY RIVSQAPSTP SPNMFTINNE TGDIITVAAG LDREKVQQYT LIIQATDMEG NPTYGLSNTA TAVITVTDVN DNPPEFTAMT FYGEVPENRV DIIVANLTVT DKDQPHTPAW NAVYRISGGD PTGRFAIQTD PNSNDGLVTV VKPIDFETNR MFVLTVAAEN QVPLAKGIQH PPQSTATVSV TVIDVNENPY FAPNPKIIRQ EEGLHAGTML TTFTAQDPDR YMQQNIRYTK LSDPANWLKI DPVNGQITTI AVLDRESPNV KNNIYNATFL ASDNGIPPMS GTGTLQIYLL DINDNAPQVL PQEAETCETP DPNSINITAL DYDIDPNAGP FAFDLPLSPV TIKRNWTITR LNGDFAQLNL KIKFLEAGIY EVPIIITDSG NPPKSNISIL RVKVCQCDSN GDCTDVDRIV GAGLGTGAHH HHHH.

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution
Protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 20% glycerol

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles

Molecular Weight

97,040 Da

OMIM

X54315 mRNA

3D Structure

ModBase 3D Structure for P19022

Product Categories/Family for CDH2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Cadherin; CDH2 Human

Other Notes

Small volumes of CDH2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDH2 purchase

MBS147244 is a recombinant protein targeting CDH2. Also known as Recombinant Human Cadherin 2. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CDH2. It may not necessarily be applicable to this product.

NCBI GI #

116241277

NCBI GeneID

1000

NCBI Accession #

P19022.4

UniProt Primary Accession #

P19022

UniProt Secondary Accession #

Q14923; Q8N173; A8MWK3; B0YIY6

UniProt Related Accession #

P19022

NCBI Official Full Name

Cadherin-2

NCBI Official Synonym Full Names

cadherin 2

NCBI Official Symbol

CDH2

NCBI Official Synonym Symbols

CDHN; NCAD; CD325; CDw325

UniProt Protein Name

Cadherin-2

UniProt Synonym Protein Names

CDw325; Neural cadherin; N-cadherin; CD_antigen: CD325

Protein Family

Cadherin

UniProt Gene Name

CDH2

UniProt Synonym Gene Names

CDHN; NCAD; N-cadherin

NCBI Protein Information

cadherin-2

NCBI Summary for CDH2

This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]

UniProt Comments for CDH2

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density ().

Research Articles on CDH2

1. Sec8 regulates N-cadherin expression by controlling Smad3 and Smad4 expression through CBP, thereby mediating the epithelial-mesenchymal transition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDH2 recombinant protein

Reference Product	PubMed Publications
CTNNB1 recombinant protein	>70 publications with CDH2 and CTNNB1
MMP9 recombinant protein	>11 publications with CDH2 and MMP9
JUP recombinant protein	>4 publications with CDH2 and JUP
CTNNA1 recombinant protein	>3 publications with CDH2 and CTNNA1
CTNND1 recombinant protein	>2 publications with CDH2 and CTNND1
SPAG9 recombinant protein	>1 publications with CDH2 and SPAG9
LRP5 recombinant protein	>1 publications with CDH2 and LRP5
FGFR1 recombinant protein	>1 publications with CDH2 and FGFR1

Pathways associated with CDH2 recombinant protein

Products by Pathway	Pathway Diagram
Adherens Junctions Interactions Pathway antibodies	Adherens Junctions Interactions Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
CDO In Myogenesis Pathway antibodies	CDO In Myogenesis Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram

Diseases associated with CDH2 recombinant protein

Disease Name	Pubmed Publications
Neoplasm Metastasis Antibodies	>44 publications with CDH2 and Neoplasm Metastasis
Disease Progression Antibodies	>30 publications with CDH2 and Disease Progression
Breast Neoplasms Antibodies	>27 publications with CDH2 and Breast Neoplasms
Cardiovascular Diseases Antibodies	>20 publications with CDH2 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>19 publications with CDH2 and Disease Models, Animal
Heart Diseases Antibodies	>15 publications with CDH2 and Heart Diseases
Neoplasms, Experimental Antibodies	>14 publications with CDH2 and Neoplasms, Experimental
Prostatic Neoplasms Antibodies	>13 publications with CDH2 and Prostatic Neoplasms
Liver Neoplasms Antibodies	>13 publications with CDH2 and Liver Neoplasms
Liver Diseases Antibodies	>12 publications with CDH2 and Liver Diseases

Organs/Tissues associated with CDH2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>53 publications with CDH2 and Muscle
Brain Antibodies	>49 publications with CDH2 and Brain
Embryonic Tissue Antibodies	>42 publications with CDH2 and Embryonic Tissue
Heart Antibodies	>34 publications with CDH2 and Heart
Vascular Antibodies	>32 publications with CDH2 and Vascular
Lung Antibodies	>31 publications with CDH2 and Lung
Bone Antibodies	>30 publications with CDH2 and Bone
Eye Antibodies	>22 publications with CDH2 and Eye
Liver Antibodies	>21 publications with CDH2 and Liver
Prostate Antibodies	>16 publications with CDH2 and Prostate