Human NECTIN2 Recombinant Protein – Cat# MBS147250

Nectin Cell Adhesion Molecule 2 (NECTIN2) Human Recombinant Protein

Name: NECTIN2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147250
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147250

Description: NECTIN2 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 337 amino acids (32-360a.a.) and having a molecular mass of 36.3kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nectin Cell Adhesion Molecule 2 (NECTIN2), Recombinant Protein

Full Product Name

Recombinant Human Nectin Cell Adhesion Molecule 2

Product Gene Name

NECTIN2 recombinant protein

Product Synonym Names

Nectin-2; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2; CD112; HVEB; PRR2; PVRL2; NECTIN2 Human; Nectin Cell Adhesion Molecule 2 Human Recombinant

Sequence

QDVRVQVLPE VRGQLGGTVE LPCHLLPPVP GLYISLVTWQ RPDAPANHQN VAAFHPKMGP SFPSPKPGSE RLSFVSAKQS TGQDTEAELQ DATLALHGLT VEDEGNYTCE FATFPKGSVR GMTWLRVIAK PKNQAEAQKV TFSQDPTTVA LCISKEGRPP ARISWLSSLD WEAKETQVSG TLAGTVTVTS RFTLVPSGRA DGVTVTCKVE HESFEEPALI PVTLSVRYPP EVSISGYDDN WYLGRTDATL SCDVRSNPEP TGYDWSTTSG TFPTSAVAQG SQLVIHAVDS LFNTTFVCTV TNAVGMGRAE QVIFVRETPN TAGAGATGGL EHHHHHH.

Host

Sf9, Insect cells

Form/Format

Protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles

Molecular Weight

51,359 Da

OMIM

X80038 mRNA

3D Structure

ModBase 3D Structure for Q92692

Product Categories/Family for NECTIN2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; NECTIN; NECTIN2 Human

Other Notes

Small volumes of NECTIN2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NECTIN2 purchase

MBS147250 is a recombinant protein targeting NECTIN2. Also known as Recombinant Human Nectin Cell Adhesion Molecule 2. Host: Sf9, Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for NECTIN2. It may not necessarily be applicable to this product.

NCBI GI #

12643789

NCBI GeneID

5819

NCBI Accession #

Q92692.1

UniProt Primary Accession #

Q92692

UniProt Secondary Accession #

O75455; Q6IBI6; Q96J29; A8K5L5

UniProt Related Accession #

Q92692

NCBI Official Full Name

Nectin-2

NCBI Official Synonym Full Names

nectin cell adhesion molecule 2

NCBI Official Symbol

NECTIN2

NCBI Official Synonym Symbols

HVEB; PRR2; CD112; PVRL2; PVRR2

UniProt Protein Name

Nectin-2

UniProt Synonym Protein Names

Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin cell adhesion molecule 2

Protein Family

Nectin

UniProt Gene Name

NECTIN2

UniProt Synonym Gene Names

Herpesvirus entry mediator B; HveB

NCBI Protein Information

nectin-2

NCBI Summary for NECTIN2

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for NECTIN2

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).

Research Articles on NECTIN2

1. In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin-2Ig.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NECTIN2 recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Adherens Junctions Interactions Pathway antibodies	Adherens Junctions Interactions Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-cell Junction Organization Pathway antibodies	Cell-cell Junction Organization Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram

Diseases associated with NECTIN2 recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>1 publications with NECTIN2 and Necrosis

Organs/Tissues associated with NECTIN2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with NECTIN2 and Blood
Embryonic Tissue Antibodies	>1 publications with NECTIN2 and Embryonic Tissue
Placenta Antibodies	>1 publications with NECTIN2 and Placenta
Testis Antibodies	>1 publications with NECTIN2 and Testis