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Fc Fragment of IgA Receptor (FCAR) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147260

Description: FCAR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 215 amino acids (22-227a.a.) and having a molecular mass of 24.5kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). FCAR is… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fc Fragment Of IgA Receptor (FCAR), Recombinant Protein
Full Product Name
Recombinant Human Fc Fragment Of IgA Receptor
Product Gene Name
FCAR recombinant protein
Product Synonym Names
Fc Fragment Of IgA Receptor; Fc Fragment Of IgA; Receptor For; CD89; Immunoglobulin Alpha Fc Receptor; Fc Alpha Receptor; FCAR Variant 14; IgA Fc Receptor; CD89 Antigen; CTB-61M7.2; FcalphaRI; Immunoglobulin alpha Fc receptor; IgA Fc receptor; FCAR Human; Fc Fragment Of IgA Receptor Human Recombinant
Sequence
ADP QEGDFPM PFISAKSSPV IPLDGSVKIQ CQAIREAYLT QLMIIKNSTY REIGRRLKFW NETDPEFVID HMDANKAGRY QCQYRIGHYR FRYSDTLELV VTGLYGKPFL SADRGLVLMP GENISLTCSS AHIPFDRFSL AKEGELSLPQ HQSGEHPANF SLGPVDLNVS GIYRCYGWYN RSPYLWSFPS NALELVVTDS IHQDYTTQNH HHHHH.
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered colorless solution
Protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Molecular Weight
28,343 Da
OMIM
X54150 mRNA
3D Structure
ModBase 3D Structure for P24071

Product Categories/Family for FCAR recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Other; FCAR Human

Other Notes

Small volumes of FCAR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCAR purchase

MBS147260 is a recombinant protein targeting FCAR. Also known as Recombinant Human Fc Fragment Of IgA Receptor. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for FCAR. It may not necessarily be applicable to this product.

NCBI GI #
119860
NCBI GeneID
2204
NCBI Accession #
P24071.1
UniProt Primary Accession #
P24071
UniProt Secondary Accession #
Q13603; Q13604; Q15727; Q15728; Q1AJL7; Q1AJL8; Q1AJL9; Q53X38; Q53X39; Q92587; Q92588
UniProt Related Accession #
P24071
NCBI Official Full Name
Immunoglobulin alpha Fc receptor
NCBI Official Synonym Full Names
Fc fragment of IgA receptor
NCBI Official Symbol
FCAR
NCBI Official Synonym Symbols
CD89; FcalphaRI; CTB-61M7.2
UniProt Protein Name
Immunoglobulin alpha Fc receptor
UniProt Synonym Protein Names
CD_antigen: CD89
Protein Family
Immunoglobulin alpha Fc receptor
UniProt Gene Name
FCAR
UniProt Synonym Gene Names
CD89; IgA Fc receptor
NCBI Protein Information
immunoglobulin alpha Fc receptor

NCBI Summary for FCAR

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for FCAR

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Research Articles on FCAR

1. In transgenic mice, IgAN pathogenesis involves impaired clearance of abnormal IgA via CD89, primarily by the Kupffer cells. Conditional IgAN progression in CD89 transgenic mice thus reveals important aspects of IgAN pathogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FCAR recombinant protein

 Products by Pathway  Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram

Diseases associated with FCAR recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with FCAR and Inflammation
 Heart Diseases Antibodies  >1 publications with FCAR and Heart Diseases
 Weight Gain Antibodies  >1 publications with FCAR and Weight Gain
 Adenoma Antibodies  >1 publications with FCAR and Adenoma
 Necrosis Antibodies  >1 publications with FCAR and Necrosis
 Liver Diseases Antibodies  >1 publications with FCAR and Liver Diseases
 Carcinoma Antibodies  >1 publications with FCAR and Carcinoma

Organs/Tissues associated with FCAR recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with FCAR and Blood
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