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Cd16b (FCGR3B) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147275

Description: FCGR3B produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 188 amino acids (21-200a.a.) and having a molecular mass of 21.4kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). FCGR3B is… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD16b (FCGR3B), Recombinant Protein
Full Product Name
Recombinant Human CD16b
Product Gene Name
FCGR3B recombinant protein
Product Synonym Names
Fc Fragment Of IgG Receptor IIIb; Fc Fragment Of IgG; Low Affinity IIIb; Receptor (CD16b); Fc Gamma Receptor IIIb; IgG Fc Receptor III-1; Fc-Gamma RIII-Beta; Fc-Gamma RIIIb; FCRIIIb; FCR-10; FCRIII; FCGR3; CD16b; FCG3; Fc Fragment Of IgG; Low Affinity IIIb; Receptor For (CD16); Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B; Fc-Gamma Receptor IIIb (CD 16); Fc-Gamma RIII; CD16b Antigen; IGFR3; CD16; FCGR3B Human; CD16b Human Recombinant
Sequence
EDLPKAVVFL EPQWYSVLEK DSVTLKCQGA YSPEDNSTQW FHNENLISSQ ASSYFIDAAT VNDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKDRKY FHHNSDFHIP KATLKDSGSY FCRGLVGSKN VSSETVNITI TQGLAVSTIS VEHHHHHH.
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered colorless solution
Protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Molecular Weight
26,216 Da
OMIM
X16863 mRNA
3D Structure
ModBase 3D Structure for O75015

Product Categories/Family for FCGR3B recombinant protein

Recombinant & Natural Proteins; CD Antigens; Fc Fragment of IgG Receptor; FCGR3B Human

Other Notes

Small volumes of FCGR3B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCGR3B purchase

MBS147275 is a recombinant protein targeting FCGR3B. Also known as Recombinant Human CD16b. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR3B. It may not necessarily be applicable to this product.

NCBI GI #
7994572
NCBI GeneID
2215
NCBI Accession #
O75015.2
UniProt Primary Accession #
O75015
UniProt Related Accession #
O75015
NCBI Official Full Name
Low affinity immunoglobulin gamma Fc region receptor III-B
NCBI Official Synonym Full Names
Fc fragment of IgG receptor IIIb
NCBI Official Symbol
FCGR3B
NCBI Official Synonym Symbols
CD16; FCG3; CD16A; CD16b; FCGR3; FCGR3A; FCR-10; FCRIII; FCRIIIb
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor III-B
UniProt Synonym Protein Names
Fc-gamma RIII-beta; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb; FcR-10; IgG Fc receptor III-1; CD_antigen: CD16b
Protein Family
Low affinity immunoglobulin gamma Fc region receptor
UniProt Gene Name
FCGR3B
UniProt Synonym Gene Names
CD16B; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor III-B

NCBI Summary for FCGR3B

The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
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UniProt Comments for FCGR3B

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
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Research Articles on FCGR3B

1. Data suggest association of FCGR3B deletion with increased risk of rheumatoid arthritis (RA) in a large cohort.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FCGR3B recombinant protein

 Reference Product  PubMed Publications
 FCGR3A recombinant protein  >59 publications with FCGR3B and FCGR3A
 SYK recombinant protein  >6 publications with FCGR3B and SYK
 APCS recombinant protein  >4 publications with FCGR3B and APCS
 CD28 recombinant protein  >4 publications with FCGR3B and CD28
 CD2 recombinant protein  >4 publications with FCGR3B and CD2

Pathways associated with FCGR3B recombinant protein

 Products by Pathway  Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram

Diseases associated with FCGR3B recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >83 publications with FCGR3B and Inflammation
 Necrosis Antibodies  >64 publications with FCGR3B and Necrosis
 Cardiovascular Diseases Antibodies  >64 publications with FCGR3B and Cardiovascular Diseases
 Syndrome Antibodies  >35 publications with FCGR3B and Syndrome
 Lung Diseases Antibodies  >29 publications with FCGR3B and Lung Diseases
 Nervous System Diseases Antibodies  >18 publications with FCGR3B and Nervous System Diseases
 Lupus Nephritis Antibodies  >17 publications with FCGR3B and Lupus Nephritis
 Pain Antibodies  >8 publications with FCGR3B and Pain
 Agranulocytosis Antibodies  >7 publications with FCGR3B and Agranulocytosis
 Granulomatosis with Polyangiitis Antibodies  >7 publications with FCGR3B and Granulomatosis with Polyangiitis

Organs/Tissues associated with FCGR3B recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >395 publications with FCGR3B and Blood
 Kidney Antibodies  >23 publications with FCGR3B and Kidney
 Lung Antibodies  >17 publications with FCGR3B and Lung
 Uterus Antibodies  >13 publications with FCGR3B and Uterus
 Liver Antibodies  >8 publications with FCGR3B and Liver
 Brain Antibodies  >8 publications with FCGR3B and Brain
 Placenta Antibodies  >7 publications with FCGR3B and Placenta
 Prostate Antibodies  >3 publications with FCGR3B and Prostate
 Pancreas Antibodies  >2 publications with FCGR3B and Pancreas
 Stomach Antibodies  >2 publications with FCGR3B and Stomach
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