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Cornulin (CRNN) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1472959

This gene encodes a member of the fused gene family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and… More details

$1295 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cornulin (CRNN), Recombinant Protein
Full Product Name
Recombinant Human Cornulin (CRNN)
Product Gene Name
CRNN recombinant protein
Product Synonym Gene Name
CRNN
Sequence
MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP GVQTQGQATG SAWVSSYDRQ AESQSQERIS PQIQLSGQTE QTQKAGEGKR NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ TVEQDSSHQT GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQ AVTGGHTQIQ AGSHTETVEQ DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP GGQAQTGAST ESGRQEWSST HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG ITARELYSYL RSTKP
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
53,533 Da
Sequence Positions
1-495, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
611312
3D Structure
ModBase 3D Structure for Q9UBG3
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CRNN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRNN purchase

MBS1472959 is a recombinant protein targeting CRNN. Also known as Recombinant Human Cornulin (CRNN). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CRNN. It may not necessarily be applicable to this product.

NCBI GI #
7706635
NCBI GeneID
49860
NCBI Accession #
NP_057274.1
UniProt Primary Accession #
Q9UBG3
UniProt Secondary Accession #
Q8N613; B2RE60
UniProt Related Accession #
Q9UBG3
GenBank Nucleotide #
NM_016190.2
NCBI Official Full Name
cornulin
NCBI Official Synonym Full Names
cornulin
NCBI Official Symbol
CRNN
NCBI Official Synonym Symbols
DRC1; PDRC1; SEP53; C1orf10
UniProt Protein Name
Cornulin
UniProt Synonym Protein Names
53 kDa putative calcium-binding protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; Squamous epithelial heat shock protein 53; Tumor-related protein
Protein Family
Cornulin
UniProt Gene Name
CRNN
UniProt Synonym Gene Names
C1orf10; DRC1; PDRC1; SEP53
NCBI Protein Information
cornulin

NCBI Summary for CRNN

This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
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UniProt Comments for CRNN

Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
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Research Articles on CRNN

1. This study showed a significant correlation between LOH/MSI at 1q21.3 with clinical outcomes and that downregulation of CRNN gene could be considered as a prognostic marker of OSCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CRNN recombinant protein

 Reference Product  PubMed Publications
 SPRR3 recombinant protein  >1 publications with CRNN and SPRR3

Diseases associated with CRNN recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with CRNN and Kidney Diseases
 Renal Insufficiency Antibodies  >1 publications with CRNN and Renal Insufficiency
 Anemia Antibodies  >1 publications with CRNN and Anemia
 Precancerous Conditions Antibodies  >1 publications with CRNN and Precancerous Conditions
 Neurodegenerative Diseases Antibodies  >1 publications with CRNN and Neurodegenerative Diseases

Organs/Tissues associated with CRNN recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >4 publications with CRNN and Skin
 Esophagus Antibodies  >4 publications with CRNN and Esophagus
 Muscle Antibodies  >1 publications with CRNN and Muscle
 Cervix Antibodies  >1 publications with CRNN and Cervix
 Mouth Antibodies  >1 publications with CRNN and Mouth
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