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RAS Guanyl-Releasing Protein 1 (RASGRP1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1474297

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the… More details

$1675 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RAS guanyl-releasing protein 1 (Rasgrp1), Recombinant Protein
Full Product Name
Recombinant Rat RAS guanyl-releasing protein 1 (Rasgrp1)
Product Gene Name
Rasgrp1 recombinant protein
Product Synonym Gene Name
Rasgrp1
Sequence
MGTLGKAREA PRKPCHGSRA GPKGRLEAKS TNSPLPAQPS LAQITQFRMM VSLGHLAKGA SLDDLIDSCI QSFDADGNLC RSNQLLQVML TMHRIIISSA ELLQKLMNLY KDALEKNSPG ICLKICYFVR YWITEFWIMF KMDASLTSTM EEFQDLVKAN GEESHCHLID TTQINSRDWS RKLTQRIKSN TSKKRKVSLL FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE NPTMERSIAL CNGISQWVQL MVLSRPTPQL RAEVFIKFIH VAQKLHQLQN FNTLMAVIGG LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSCRNYDNY RRAYGECTHF KIPILGVHLK DLISLYEAMP DYLEDGKVNV QKLLALYNHI NELVQLQDVA PPLDANKDLV HLLTLSLDLY YTEDEIYELS YAREPRNHRA PPLTPSKPPV VVDWASGVSP KPDPKTISKH VQRMVDSVFK NYDLDQDGYI SQEEFEKIAA SFPFSFCVMD KDREGLISRD EITAYFMRAS SIYSKLGLGF PHNFQETTYL KPTFCDNCAG FLWGVIKQGY RCKDCGMNCH KQCKDLVVFE CKKRSKSPAV STENISSVVP MSTLCPLGTK DLLHAPEEGS FIFQNGEVVD HSEESKDRTI MLLGVSSQKI SVRLKRTVAH KTTQTESFPW VGGEMPPGHF VLTSPRKSAQ GALYVHSPAS PCPSPALVRK RAFVKWENKE SLIKPKPELH LRLRTYQELE QEVNTLRADN DALKIQLKYA QKQIESLQLG KSNHVLAQMD HGDGT
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
90,245 Da
Sequence Positions
1-795, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9R1K8
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Rasgrp1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Rasgrp1 purchase

MBS1474297 is a recombinant protein targeting Rasgrp1. Also known as Recombinant Rat RAS guanyl-releasing protein 1 (Rasgrp1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Rasgrp1. It may not necessarily be applicable to this product.

NCBI GI #
31377530
NCBI GeneID
29434
NCBI Accession #
NP_062084.2
UniProt Primary Accession #
Q9R1K8
UniProt Secondary Accession #
O88469
UniProt Related Accession #
Q9R1K8
GenBank Nucleotide #
NM_019211.2
NCBI Official Full Name
RAS guanyl-releasing protein 1
NCBI Official Synonym Full Names
RAS guanyl releasing protein 1
NCBI Official Symbol
Rasgrp1
NCBI Official Synonym Symbols
Rasgrp
UniProt Protein Name
RAS guanyl-releasing protein 1
UniProt Synonym Protein Names
Calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEFII; Ras guanyl-releasing protein
Protein Family
RAS guanyl-releasing protein
UniProt Gene Name
Rasgrp1
UniProt Synonym Gene Names
Rasgrp; CalDAG-GEFII
NCBI Protein Information
RAS guanyl-releasing protein 1

NCBI Summary for Rasgrp1

putative guanine nucleotide exchange factor with Ca2+ and diacylglycerol binding domains; may activate Rap protein mediated inhibition of Ras signaling pathways [RGD, Feb 2006]

UniProt Comments for Rasgrp1

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:9789079, PubMed:9582122). Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated ().
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Research Articles on Rasgrp1

1. RasGRP1 is a diacylglycerol/phorbol ester receptor in epidermal keratinocytes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Rasgrp1 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Effects Of PIP2 Hydrolysis Pathway antibodies  Effects Of PIP2 Hydrolysis Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Integrin AlphaIIb Beta3 Signaling Pathway antibodies  Integrin AlphaIIb Beta3 Signaling Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with Rasgrp1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >17 publications with Rasgrp1 and Neoplasms
 Immune System Diseases Antibodies  >17 publications with Rasgrp1 and Immune System Diseases
 Necrosis Antibodies  >4 publications with Rasgrp1 and Necrosis
 Drug Toxicity Antibodies  >4 publications with Rasgrp1 and Drug Toxicity
 Leukemia, Myeloid, Acute Antibodies  >4 publications with Rasgrp1 and Leukemia, Myeloid, Acute
 Nervous System Diseases Antibodies  >3 publications with Rasgrp1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >2 publications with Rasgrp1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >2 publications with Rasgrp1 and Disease Models, Animal
 Thrombosis Antibodies  >1 publications with Rasgrp1 and Thrombosis
 Inflammation Antibodies  >1 publications with Rasgrp1 and Inflammation

Organs/Tissues associated with Rasgrp1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with Rasgrp1 and Brain
 Thymus Antibodies  >12 publications with Rasgrp1 and Thymus
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