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Glutaminase Liver Isoform, Mitochondrial (GLS2) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1475627

This protein is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size.… More details

$1380 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glutaminase liver isoform, mitochondrial (Gls2), Recombinant Protein
Full Product Name
Recombinant Mouse Glutaminase liver isoform, mitochondrial (Gls2)
Product Gene Name
Gls2 recombinant protein
Product Synonym Gene Name
Gls2
Sequence
GSHGRRGGWG HPSRGPLLGR GVRYYLGEAA AQGRGTPHSH QPQHSDHDAS HSGMLPRLGD LLFYTIAEGQ ERIPIHKFTT ALKATGLQTS DPRLQDCMSK MQRMVQESSS GGLLDRELFQ KCVSSNIVLL TQAFRKKFVI PDFEEFTGHV DRIFEDAKEP TGGKVAAYIP HLAKSNPDLW GVSLCTVDGQ RHSVGHTKIP FCLQSCVKPL TYAISVSTLG TDYVHKFVGK EPSGLRYNKL SLNEEGIPHN PMVNAGAIVV SSLIKMDCNK AEKFDFVLQY LNKMAGNEFM GFSNATFQSE KETGDRNYAI GYYLKEKKCF PKGVDMMAAL DLYFQLCSVE VTCESGSVMA ATLANGGICP ITGESVLSAE AVRNTLSLMH SCGMYDFSGQ FAFHVGLPAK SAVSGAILLV VPNVMGMMCL SPPLDKLGNS QRGINFCQKL VSLFNFHNYD NLRHCARKLD PRREGGEVRN KTVVNLLFAA YSGDVSALRR FALSAMDMEQ KDYDSRTALH VAAAEGHIEV VKFLIEACKV NPFVKDRWGN IPLDDAVQFN HLEVVKLLQD YHDSYLLSET QAEAAAETLS KENLESMV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
66,366 Da
Sequence Positions
15-602, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q571F8
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Gls2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gls2 purchase

MBS1475627 is a recombinant protein targeting Gls2. Also known as Recombinant Mouse Glutaminase liver isoform, mitochondrial (Gls2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Gls2. It may not necessarily be applicable to this product.

NCBI GI #
254826698
NCBI GeneID
216456
NCBI Accession #
NP_001028436.2
UniProt Primary Accession #
Q571F8
UniProt Secondary Accession #
Q3TMJ6; B2RUF2
UniProt Related Accession #
Q571F8
GenBank Nucleotide #
NM_001033264.3
NCBI Official Full Name
glutaminase liver isoform, mitochondrial isoform 1
NCBI Official Synonym Full Names
glutaminase 2 (liver, mitochondrial)
NCBI Official Symbol
Gls2
NCBI Official Synonym Symbols
GA; GLS; Lga; AI195532; A330074B06Rik
UniProt Protein Name
Glutaminase liver isoform, mitochondrial
UniProt Synonym Protein Names
L-glutaminase; L-glutamine amidohydrolase
Protein Family
Glucosidase
UniProt Gene Name
Gls2
UniProt Synonym Gene Names
Kiaa4146; GLS
NCBI Protein Information
glutaminase liver isoform, mitochondrial

UniProt Comments for Gls2

Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production ().

Research Articles on Gls2

1. Gls2 expression is regulated by the dietary protein/carbohydrate ratio. This effect was not observed in Ppara-null mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Gls2 recombinant protein

 Reference Product  PubMed Publications
 Glul recombinant protein  >2 publications with Gls2 and Glul
 Cps1 recombinant protein  >2 publications with Gls2 and Cps1

Pathways associated with Gls2 recombinant protein

 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 D-Glutamine And D-glutamate Metabolism Pathway antibodies  D-Glutamine And D-glutamate Metabolism Pathway Diagram
 D-Glutamine And D-glutamate Metabolism Pathway antibodies  D-Glutamine And D-glutamate Metabolism Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram

Diseases associated with Gls2 recombinant protein

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >9 publications with Gls2 and Liver Diseases
 Liver Neoplasms Antibodies  >8 publications with Gls2 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >7 publications with Gls2 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >3 publications with Gls2 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >2 publications with Gls2 and Kidney Diseases
 Disease Models, Animal Antibodies  >2 publications with Gls2 and Disease Models, Animal
 Lung Neoplasms Antibodies  >2 publications with Gls2 and Lung Neoplasms
 Lung Diseases Antibodies  >2 publications with Gls2 and Lung Diseases
 Poisoning Antibodies  >1 publications with Gls2 and Poisoning
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with Gls2 and Drug-Related Side Effects and Adverse Reactions

Organs/Tissues associated with Gls2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >15 publications with Gls2 and Liver
 Brain Antibodies  >12 publications with Gls2 and Brain
 Lung Antibodies  >3 publications with Gls2 and Lung
 Thymus Antibodies  >1 publications with Gls2 and Thymus
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