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DNA-Dependent Protein Kinase Catalytic Subunit (PRKDC) Chicken Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1477051

MBS1477051 is a recombinant protein targeting PRKDC. Also known as Recombinant Chicken DNA-dependent protein kinase catalytic subunit (PRKDC), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1150 / 0.05 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNA-dependent protein kinase catalytic subunit (PRKDC), Recombinant Protein
Full Product Name
Recombinant Chicken DNA-dependent protein kinase catalytic subunit (PRKDC), partial
Product Gene Name
PRKDC recombinant protein
Product Synonym Gene Name
PRKDC
Sequence
ISGFDERIMV LESLRKPKRI TIRGSDEQEH PFLVKGGEDL RQDQRIEQLF DVMNIVLSRD AACSQRNMQL KTYQVIPMTT RLGLIKWLEN TCTLKEFLRN SMTEEEDANY NSLKGPRAAY SDWLSKMGGK AQGLSRYNAM YKNASRTETV IAFKSRESSV PEDLLRRAFV KMSTSPEAFL ALRSHFVSSH ALMCVSHWIL GIGDRHLSNF MINKETGGMV GIDFGHAFGS ATQFLPVPEL MPFRLTRQFV NLMMPVKEWG LIYSVMVHAL RAYRADPDLL ISTMDVFVKE PSLDWKNFEQ RQLKKGGTWI KEINTAEVNW YPLQKVSYVK RKLTGANPAR ITCDELRLGY EKLPFYNDFA AVARGSADHN IRAKEPEDRL SEETQVRCLI DQATDPNLLG RVWEGWEPWM
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
472,657 Da
Sequence Positions
3725-4134. Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8QGX4
Species
Chicken
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PRKDC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PRKDC. It may not necessarily be applicable to this product.

NCBI GI #
742799250
NCBI GeneID
395376
NCBI Accession #
NP_989989.2
UniProt Primary Accession #
Q8QGX4
UniProt Secondary Accession #
P79791; Q9DEI2
UniProt Related Accession #
Q8QGX4
GenBank Nucleotide #
NM_204658.2
NCBI Official Full Name
DNA-dependent protein kinase catalytic subunit
NCBI Official Synonym Full Names
protein kinase, DNA-activated, catalytic polypeptide
NCBI Official Symbol
PRKDC
NCBI Official Synonym Symbols
dnapkcs; DNA-PKCS
UniProt Protein Name
DNA-dependent protein kinase catalytic subunit
UniProt Gene Name
PRKDC
UniProt Synonym Gene Names
XRCC7; DNA-PK catalytic subunit; DNA-PKcs
NCBI Protein Information
DNA-dependent protein kinase catalytic subunit

UniProt Comments for PRKDC

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism ().
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Research Articles on PRKDC

1. KU70 and DNA-PKcs unexpectedly function together during the induction of apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRKDC recombinant protein

 Reference Product  PubMed Publications
 XRCC5 recombinant protein  >169 publications with PRKDC and XRCC5
 XRCC4 recombinant protein  >59 publications with PRKDC and XRCC4
 DCLRE1C recombinant protein  >18 publications with PRKDC and DCLRE1C
 NHEJ1 recombinant protein  >5 publications with PRKDC and NHEJ1
 C1D recombinant protein  >3 publications with PRKDC and C1D
 LIG4 recombinant protein  >3 publications with PRKDC and LIG4
 XRCC6 recombinant protein  >3 publications with PRKDC and XRCC6
 CHEK1 recombinant protein  >2 publications with PRKDC and CHEK1
 TDP1 recombinant protein  >1 publications with PRKDC and TDP1

Pathways associated with PRKDC recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Non-homologous End-joining Pathway antibodies  Non-homologous End-joining Pathway Diagram
 Non-homologous End-joining Pathway antibodies  Non-homologous End-joining Pathway Diagram

Diseases associated with PRKDC recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >50 publications with PRKDC and Nervous System Diseases
 Chromosome Aberrations Antibodies  >49 publications with PRKDC and Chromosome Aberrations
 Disease Models, Animal Antibodies  >47 publications with PRKDC and Disease Models, Animal
 Breast Neoplasms Antibodies  >33 publications with PRKDC and Breast Neoplasms
 Lymphoma Antibodies  >31 publications with PRKDC and Lymphoma
 Lung Neoplasms Antibodies  >20 publications with PRKDC and Lung Neoplasms
 Lung Diseases Antibodies  >19 publications with PRKDC and Lung Diseases
 Prostatic Neoplasms Antibodies  >15 publications with PRKDC and Prostatic Neoplasms
 Ovarian Neoplasms Antibodies  >14 publications with PRKDC and Ovarian Neoplasms
 Liver Diseases Antibodies  >14 publications with PRKDC and Liver Diseases

Organs/Tissues associated with PRKDC recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >181 publications with PRKDC and Other
 Brain Antibodies  >39 publications with PRKDC and Brain
 Liver Antibodies  >31 publications with PRKDC and Liver
 Ovary Antibodies  >13 publications with PRKDC and Ovary
 Head Antibodies  >12 publications with PRKDC and Head
 Embryonic Tissue Antibodies  >9 publications with PRKDC and Embryonic Tissue
 Pancreas Antibodies  >5 publications with PRKDC and Pancreas
 Whole Body Antibodies  >5 publications with PRKDC and Whole Body
 Small Intestine Antibodies  >3 publications with PRKDC and Small Intestine
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