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Wd Repeat and FYVE Domain-Containing Protein 1 (WDFY1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1477176

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains a single FYVE domain and multiple WD40… More details

$335 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
WD repeat and FYVE domain-containing protein 1 (WDFY1), Recombinant Protein
Full Product Name
Recombinant Human WD repeat and FYVE domain-containing protein 1 (WDFY1)
Product Gene Name
WDFY1 recombinant protein
Product Synonym Gene Name
WDFY1
Sequence
MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV WLKRDSGQYW PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED FNKMNFIKTY PAHQNRVSAI IFSLATEWVI STGHDKCVSW MCTRSGNMLG RHFFTSWASC LQYDFDTQYA FVGDYSGQIT LLKLEQNTCS VITTLKGHEG SVACLWWDPI QRLLFSGASD NSIIMWDIGG RKGRTLLLQG HHDKVQSLCY LQLTRQLVSC SSDGGIAVWN MDVSREEAPQ WLESDSCQKC EQPFFWNIKQ MWDTKTLGLR QHHCRKCGQA VCGKCSSKRS SYPVMGFEFQ VRVCDSCYDS IKDEDRTSLA TFHEGKHNIS HMSMDIARGL MVTCGTDRIV KIWDMTPVVG CSLATGFSPH
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
46,324 Da
Sequence Positions
1-410, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8IWB7
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of WDFY1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WDFY1 purchase

MBS1477176 is a recombinant protein targeting WDFY1. Also known as Recombinant Human WD repeat and FYVE domain-containing protein 1 (WDFY1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for WDFY1. It may not necessarily be applicable to this product.

NCBI GI #
18482373
NCBI GeneID
57590
NCBI Accession #
NP_065881.1
UniProt Primary Accession #
Q8IWB7
UniProt Secondary Accession #
Q53S17; Q9H9D5; Q9P2B3
UniProt Related Accession #
Q8IWB7
GenBank Nucleotide #
NM_020830.4
NCBI Official Full Name
WD repeat and FYVE domain-containing protein 1
NCBI Official Synonym Full Names
WD repeat and FYVE domain containing 1
NCBI Official Symbol
WDFY1
NCBI Official Synonym Symbols
WDF1; FENS-1; ZFYVE17
UniProt Protein Name
WD repeat and FYVE domain-containing protein 1
UniProt Synonym Protein Names
FENS-1; Phosphoinositide-binding protein 1; WD40- and FYVE domain-containing protein 1; Zinc finger FYVE domain-containing protein 17
Protein Family
WD repeat and FYVE domain-containing protein
UniProt Gene Name
WDFY1
UniProt Synonym Gene Names
KIAA1435; WDF1; ZFYVE17
NCBI Protein Information
WD repeat and FYVE domain-containing protein 1

NCBI Summary for WDFY1

The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]
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UniProt Comments for WDFY1

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).

Research Articles on WDFY1

1. NRP2 inhibits WDFY1 transcription by preventing the nuclear localization of a transcription factor, Fetal ALZ50-reactive clone 1 (FAC1).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with WDFY1 recombinant protein

 Reference Product  PubMed Publications
 NUDT19 recombinant protein  >1 publications with WDFY1 and NUDT19

Diseases associated with WDFY1 recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with WDFY1 and Disease Models, Animal
 Atrophy Antibodies  >2 publications with WDFY1 and Atrophy
 Fibrosis Antibodies  >1 publications with WDFY1 and Fibrosis
 Poisoning Antibodies  >1 publications with WDFY1 and Poisoning

Organs/Tissues associated with WDFY1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with WDFY1 and Brain
 Pancreas Antibodies  >1 publications with WDFY1 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with WDFY1 and Embryonic Tissue
 Vascular Antibodies  >1 publications with WDFY1 and Vascular
 Placenta Antibodies  >1 publications with WDFY1 and Placenta
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