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Telomerase Cajal Body Protein 1 (WRAP53) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1484333

MBS1484333 is a recombinant protein targeting WRAP53. Also known as Recombinant Human Telomerase Cajal body protein 1 (WRAP53). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1340 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Telomerase Cajal body protein 1 (WRAP53), Recombinant Protein
Full Product Name
Recombinant Human Telomerase Cajal body protein 1 (WRAP53)
Product Gene Name
WRAP53 recombinant protein
Product Synonym Gene Name
WRAP53
Sequence
MKTLETQPLA PDCCPSDQDP APAHPSPHAS PMNKNADSEL MPPPPERGDP PRLSPDPVAG SAVSQELREG DPVSLSTPLE TEFGSPSELS PRIEEQELSE NTSLPAEEAN GSLSEEEANG PELGSGKAME DTSGEPAAED EGDTAWNYSF SQLPRFLSGS WSEFSTQPEN FLKGCKWAPD GSCILTNSAD NILRIYNLPP ELYHEGEQVE YAEMVPVLRM VEGDTIYDYC WYSLMSSAQP DTSYVASSSR ENPIHIWDAF TGELRASFRA YNHLDELTAA HSLCFSPDGS QLFCGFNRTV RVFSTARPGR DCEVRATFAK KQGQSGIISC IAFSPAQPLY ACGSYGRSLG LYAWDDGSPL ALLGGHQGGI THLCFHPDGN RFFSGARKDA ELLCWDLRQS GYPLWSLGRE VTTNQRIYFD LDPTGQFLVS GSTSGAVSVW DTDGPGNDGK PEPVLSFLPQ KDCTNGVSLH PSLPLLATAS GQRVFPEPTE SGDEGEELGL PLLSTRHVHL ECRLQLWWCG GAPDSSIPDD HQGEKGQGGT EGGVGELI
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
59,309 Da
Sequence Positions
1-548, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
612661
3D Structure
ModBase 3D Structure for Q9BUR4
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of WRAP53 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for WRAP53. It may not necessarily be applicable to this product.

NCBI GI #
221136858
NCBI GeneID
55135
NCBI Accession #
NP_001137462.1
UniProt Primary Accession #
Q9BUR4
UniProt Secondary Accession #
Q08ET9; Q9NW09; B3KPR9; D3DTQ4
UniProt Related Accession #
Q9BUR4
GenBank Nucleotide #
NM_001143990.1
NCBI Official Full Name
telomerase Cajal body protein 1
NCBI Official Synonym Full Names
WD repeat containing antisense to TP53
NCBI Official Symbol
WRAP53
NCBI Official Synonym Symbols
DKCB3; TCAB1; WDR79
UniProt Protein Name
Telomerase Cajal body protein 1
UniProt Synonym Protein Names
WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 repeat-containing protein antisense to TP53 gene
Protein Family
Telomerase Cajal body protein
UniProt Gene Name
WRAP53
UniProt Synonym Gene Names
TCAB1; WDR79
NCBI Protein Information
telomerase Cajal body protein 1

NCBI Summary for WRAP53

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
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UniProt Comments for WRAP53

Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.
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Research Articles on WRAP53

1. The present findings indicate that WRAP53beta and RNF8 are rate-limiting factors in the repair of DNA double-strand breaks and raise the possibility that upregulation of WRAP53beta may contribute to genomic stability in and survival of cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with WRAP53 recombinant protein

 Reference Product  PubMed Publications
 TERT recombinant protein  >2 publications with WRAP53 and TERT
 DKC1 recombinant protein  >2 publications with WRAP53 and DKC1

Pathways associated with WRAP53 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Extension Of Telomeres Pathway antibodies  Extension Of Telomeres Pathway Diagram
 Telomere Extension By Telomerase Pathway antibodies  Telomere Extension By Telomerase Pathway Diagram
 Telomere Maintenance Pathway antibodies  Telomere Maintenance Pathway Diagram

Diseases associated with WRAP53 recombinant protein

 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >1 publications with WRAP53 and Central Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with WRAP53 and Cell Transformation, Neoplastic
 Atrophy Antibodies  >1 publications with WRAP53 and Atrophy
 Muscular Atrophy Antibodies  >1 publications with WRAP53 and Muscular Atrophy
 Eye Abnormalities Antibodies  >1 publications with WRAP53 and Eye Abnormalities
 Skin Diseases Antibodies  >1 publications with WRAP53 and Skin Diseases
 Fibrosis Antibodies  >1 publications with WRAP53 and Fibrosis
 Nervous System Diseases Antibodies  >1 publications with WRAP53 and Nervous System Diseases

Organs/Tissues associated with WRAP53 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with WRAP53 and Liver
 Blood Antibodies  >2 publications with WRAP53 and Blood
 Bone Antibodies  >1 publications with WRAP53 and Bone
 Muscle Antibodies  >1 publications with WRAP53 and Muscle
 Eye Antibodies  >1 publications with WRAP53 and Eye
 Bone Marrow Antibodies  >1 publications with WRAP53 and Bone Marrow
 Lung Antibodies  >1 publications with WRAP53 and Lung
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