• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Nuclear Distribution Protein Nude Homolog 1 (NDE1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1484361

MBS1484361 is a recombinant protein targeting NDE1. Also known as Recombinant Human Nuclear distribution protein nudE homolog 1 (NDE1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nuclear distribution protein nudE homolog 1 (NDE1), Recombinant Protein
Full Product Name
Recombinant Human Nuclear distribution protein nudE homolog 1 (NDE1)
Product Gene Name
NDE1 recombinant protein
Product Synonym Gene Name
NDE1
Sequence
MEDSGKTFSS EEEEANYWKD LAMTYKQRAE NTQEELREFQ EGSREYEAEL ETQLQQIETR NRDLLSENNR LRMELETIKE KFEVQHSEGY RQISALEDDL AQTKAIKDQL QKYIRELEQA NDDLERAKRA TIMSLEDFEQ RLNQAIERNA FLESELDEKE NLLESVQRLK DEARDLRQEL AVQQKQEKPR TPMPSSVEAE RTDTAVQATG SVPSTPIAHR GPSSSLNTPG SFRRGLDDST GGTPLTPAAR ISALNIVGDL LRKVGALESK LASCRNLVYD QSPNRTGGPA SGRSSKNRDG GERRPSSTSV PLGDKGLGKR LEFGKPPSHM SSSPLPSAQG VVKMLL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
37,721 Da
Sequence Positions
1-346, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605013
3D Structure
ModBase 3D Structure for Q9NXR1
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NDE1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NDE1. It may not necessarily be applicable to this product.

NCBI GI #
221316642
NCBI GeneID
54820
NCBI Accession #
NP_001137451.1
UniProt Primary Accession #
Q9NXR1
UniProt Secondary Accession #
Q49AQ2
UniProt Related Accession #
Q9NXR1
GenBank Nucleotide #
NM_001143979.1
NCBI Official Full Name
nuclear distribution protein nudE homolog 1
NCBI Official Synonym Full Names
nudE neurodevelopment protein 1
NCBI Official Symbol
NDE1
NCBI Official Synonym Symbols
NDE; LIS4; MHAC; NUDE; NUDE1; HOM-TES-87
UniProt Protein Name
Nuclear distribution protein nudE homolog 1
Protein Family
External NADH-ubiquinone oxidoreductase
UniProt Gene Name
NDE1
UniProt Synonym Gene Names
NUDE; NudE
NCBI Protein Information
nuclear distribution protein nudE homolog 1

NCBI Summary for NDE1

This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Show more

UniProt Comments for NDE1

Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.
Show more

Research Articles on NDE1

1. NDE1/Lissencephaly 1 and dynactin complexes separately mediate two key components of T cell-focused secretion, namely translocation of the MTOC and lytic granules to the IS, respectively.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NDE1 recombinant protein

 Reference Product  PubMed Publications
 PAFAH1B1 recombinant protein  >15 publications with NDE1 and PAFAH1B1
 CDK1 recombinant protein  >1 publications with NDE1 and CDK1

Pathways associated with NDE1 recombinant protein

 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram

Diseases associated with NDE1 recombinant protein

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >12 publications with NDE1 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >4 publications with NDE1 and Disease Models, Animal
 Seizures Antibodies  >2 publications with NDE1 and Seizures
 Heart Diseases Antibodies  >1 publications with NDE1 and Heart Diseases
 Breast Neoplasms Antibodies  >1 publications with NDE1 and Breast Neoplasms
 Carcinoma Antibodies  >1 publications with NDE1 and Carcinoma
 Kidney Diseases Antibodies  >1 publications with NDE1 and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with NDE1 and Liver Neoplasms
 Kidney Neoplasms Antibodies  >1 publications with NDE1 and Kidney Neoplasms
 Liver Diseases Antibodies  >1 publications with NDE1 and Liver Diseases

Organs/Tissues associated with NDE1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with NDE1 and Brain
 Nerve Antibodies  >17 publications with NDE1 and Nerve
 Eye Antibodies  >2 publications with NDE1 and Eye
 Spinal Cord Antibodies  >1 publications with NDE1 and Spinal Cord
 Embryonic Tissue Antibodies  >1 publications with NDE1 and Embryonic Tissue
 Liver Antibodies  >1 publications with NDE1 and Liver
 Heart Antibodies  >1 publications with NDE1 and Heart
 Kidney Antibodies  >1 publications with NDE1 and Kidney
 Prostate Antibodies  >1 publications with NDE1 and Prostate
 Skin Antibodies  >1 publications with NDE1 and Skin
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000