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RE1-Silencing Transcription Factor (REST) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1485048

This gene encodes a transcriptional repressor which represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the… More details

$820 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RE1-silencing transcription factor (REST), Recombinant Protein
Full Product Name
Recombinant Human RE1-silencing transcription factor (REST) , partial
Product Gene Name
REST recombinant protein
Product Synonym Gene Name
REST
Sequence
PGAEDKGKSS KTKPFRCKPC QYEAESEEQF VHHIRVHSAK KFFVEESAEK QAKARESGSS TAEEGDFSKG PIRCDRCGYN TNRYDHYTAH LKHHTRAGDN ERVYKCIICT YTTVSEYHWR KHLRNHFPRK VYTCGKCNYF SDRKNNYVQH VRTHTGERPY KCELCPYSSS QKTHLTRHMR THSGEKPFKC DQCSYVASNQ HEVTRHARQV HNGPKPLNCP HCDYKTADRS NFKKHVELHV NPRQFNCPVC DYAASKKCNL QYHFKSKHPT CPNK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
119,083 Da
Sequence Positions
145-418aa, Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
600571
3D Structure
ModBase 3D Structure for Q13127
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of REST recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for REST purchase

MBS1485048 is a recombinant protein targeting REST. Also known as Recombinant Human RE1-silencing transcription factor (REST) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for REST. It may not necessarily be applicable to this product.

NCBI GI #
301897977
NCBI GeneID
5978
NCBI Accession #
NP_001180437.1
UniProt Primary Accession #
Q13127
UniProt Secondary Accession #
Q12956; Q12957; Q13134; Q59ER1; Q8IWI3; A2RUE0; B9EGJ0
UniProt Related Accession #
Q13127
GenBank Nucleotide #
NM_001193508.1
NCBI Official Full Name
RE1-silencing transcription factor
NCBI Official Synonym Full Names
RE1 silencing transcription factor
NCBI Official Symbol
REST
NCBI Official Synonym Symbols
WT6; XBR; HGF5; NRSF; GINGF5
UniProt Protein Name
RE1-silencing transcription factor
UniProt Synonym Protein Names
Neural-restrictive silencer factor; X2 box repressor
Protein Family
RE1-silencing transcription factor
UniProt Gene Name
REST
UniProt Synonym Gene Names
NRSF; XBR
NCBI Protein Information
RE1-silencing transcription factor

NCBI Summary for REST

This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]
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UniProt Comments for REST

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.
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Research Articles on REST

1. Low REST expression is associated with prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with REST recombinant protein

 Reference Product  PubMed Publications
 HDAC1 recombinant protein  >32 publications with REST and HDAC1
 RCOR1 recombinant protein  >32 publications with REST and RCOR1
 HTT recombinant protein  >19 publications with REST and HTT
 HDAC2 recombinant protein  >11 publications with REST and HDAC2
 SIN3A recombinant protein  >10 publications with REST and SIN3A
 HCN4 recombinant protein  >7 publications with REST and HCN4
 SIN3B recombinant protein  >4 publications with REST and SIN3B
 SMARCA4 recombinant protein  >2 publications with REST and SMARCA4

Pathways associated with REST recombinant protein

 Products by Pathway  Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram

Diseases associated with REST recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7196 publications with REST and Neoplasms
 Brain Diseases Antibodies  >4500 publications with REST and Brain Diseases
 Carcinoma Antibodies  >2450 publications with REST and Carcinoma
 Drug Toxicity Antibodies  >1805 publications with REST and Drug Toxicity
 Inflammation Antibodies  >1551 publications with REST and Inflammation
 Kidney Diseases Antibodies  >1504 publications with REST and Kidney Diseases
 Hypertrophy Antibodies  >1484 publications with REST and Hypertrophy
 Liver Diseases Antibodies  >1375 publications with REST and Liver Diseases
 Hemorrhage Antibodies  >1301 publications with REST and Hemorrhage
 Necrosis Antibodies  >1289 publications with REST and Necrosis

Organs/Tissues associated with REST recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34934 publications with REST and Blood
 Heart Antibodies  >25233 publications with REST and Heart
 Muscle Antibodies  >16128 publications with REST and Muscle
 Vascular Antibodies  >11856 publications with REST and Vascular
 Brain Antibodies  >10103 publications with REST and Brain
 Bone Antibodies  >5284 publications with REST and Bone
 Lung Antibodies  >5131 publications with REST and Lung
 Nerve Antibodies  >4934 publications with REST and Nerve
 Skin Antibodies  >3591 publications with REST and Skin
 Liver Antibodies  >2866 publications with REST and Liver
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