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Pyroglutamyl-Peptidase 1 (PGPEP1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1486694

MBS1486694 is a recombinant protein targeting PGPEP1. Also known as Recombinant Human Pyroglutamyl-peptidase 1 (PGPEP1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$865 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pyroglutamyl-peptidase 1 (PGPEP1), Recombinant Protein
Full Product Name
Recombinant Human Pyroglutamyl-peptidase 1 (PGPEP1)
Product Gene Name
PGPEP1 recombinant protein
Product Synonym Gene Name
PGPEP1
Sequence
MEQPRKAVVV TGFGPFGEHT VNASWIAVQE LEKLGLGDSV DLHVYEIPVE YQTVQRLIPA LWEKHSPQLV VHVGVSGMAT TVTLEKCGHN KGYKGLDNCR FCPGSQCCVE DGPESIDSII DMDAVCKRVT TLGLDVSVTI SQDAGRYLCD FTYYTSLYQS HGRSAFVHVP PLGKPYNADQ LGRALRAIIE EMLDLLEQSE GKINYCHKH
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
14,639 Da
Sequence Positions
1-209, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
610694
3D Structure
ModBase 3D Structure for Q9NXJ5
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PGPEP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PGPEP1. It may not necessarily be applicable to this product.

NCBI GI #
665505942
NCBI GeneID
54858
NCBI Accession #
NP_001287856.1
UniProt Primary Accession #
Q9NXJ5
UniProt Secondary Accession #
Q8IVT1; A8K1Q3
UniProt Related Accession #
Q9NXJ5
GenBank Nucleotide #
NM_001300927.1
NCBI Official Full Name
pyroglutamyl-peptidase 1 isoform 2
NCBI Official Synonym Full Names
pyroglutamyl-peptidase I
NCBI Official Symbol
PGPEP1
NCBI Official Synonym Symbols
PGI; PGP; Pcp; PGPI; PAP-I; PGP-I
UniProt Protein Name
Pyroglutamyl-peptidase 1
UniProt Synonym Protein Names
5-oxoprolyl-peptidase; Pyroglutamyl aminopeptidase I; PAP-I; Pyroglutamyl-peptidase I; PGP-I; Pyrrolidone-carboxylate peptidase
Protein Family
Pyroglutamyl-peptidase
UniProt Gene Name
PGPEP1
UniProt Synonym Gene Names
PGPI; PAP-I; PGP-I
NCBI Protein Information
pyroglutamyl-peptidase 1

NCBI Summary for PGPEP1

The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
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UniProt Comments for PGPEP1

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Research Articles on PGPEP1

1. cytosolic peptidases(puromycin-sensitive aminopeptidase (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) ) may be involved in colorectal carcinogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with PGPEP1 recombinant protein

 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >1 publications with PGPEP1 and Neurobehavioral Manifestations
 Congenital Abnormalities Antibodies  >1 publications with PGPEP1 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >1 publications with PGPEP1 and Disease Models, Animal

Organs/Tissues associated with PGPEP1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >1 publications with PGPEP1 and Intestine
 Brain Antibodies  >1 publications with PGPEP1 and Brain
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