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Thiomorpholine-Carboxylate Dehydrogenase (CRYM) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1486837

Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and… More details

$1015 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Thiomorpholine-carboxylate dehydrogenase (CRYM), Recombinant Protein
Full Product Name
Recombinant Human Thiomorpholine-carboxylate dehydrogenase (CRYM)
Product Gene Name
CRYM recombinant protein
Product Synonym Gene Name
CRYM
Sequence
MSRVPAFLSA AEVEEHLRSS SLLIPPLETA LANFSSGPEG GVMQPVRTVV PVTKHRGYLG VMPAYSAAED ALTTKLVTFY EDRGITSVVP SHQATVLLFE PSNGTLLAVM DGNVITAKRT AAVSAIATKF LKPPSSEVLC ILGAGVQAYS HYEIFTEQFS FKEVRIWNRT KENAEKFADT VQGEVRVCSS VQEAVAGADV IITVTLATEP ILFGEWVKPG AHINAVGASR PDWRELDDEL MKEAVLYVDS QEAALKESGD VLLSGAEIFA ELGEVIKGVK PAHCEKTTVF KSLGMAVEDT VAAKLIYDSW SSGK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
33,776 Da
Sequence Positions
1-314, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
123740
3D Structure
ModBase 3D Structure for Q14894
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CRYM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRYM purchase

MBS1486837 is a recombinant protein targeting CRYM. Also known as Recombinant Human Thiomorpholine-carboxylate dehydrogenase (CRYM). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CRYM. It may not necessarily be applicable to this product.

NCBI GI #
4503065
NCBI GeneID
1428
NCBI Accession #
NP_001879.1
UniProt Primary Accession #
Q14894
UniProt Secondary Accession #
Q5HYB7; D5MNX0
UniProt Related Accession #
Q14894
GenBank Nucleotide #
NM_001888.4
NCBI Official Full Name
ketimine reductase mu-crystallin
NCBI Official Synonym Full Names
crystallin mu
NCBI Official Symbol
CRYM
NCBI Official Synonym Symbols
THBP; DFNA40
UniProt Protein Name
Ketimine reductase mu-crystallin
UniProt Synonym Protein Names
NADP-regulated thyroid-hormone-binding protein
Protein Family
Ketimine reductase
UniProt Gene Name
CRYM
UniProt Synonym Gene Names
THBP
NCBI Protein Information
ketimine reductase mu-crystallin

NCBI Summary for CRYM

Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014]
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UniProt Comments for CRYM

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
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Research Articles on CRYM

1. These findings confirm that, mechanistically, ketimine reductase/CRYM acts as a classical imine reductase and may explain the finding of bound pyruvate in the crystallized protein.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CRYM recombinant protein

 Reference Product  PubMed Publications
 CRYBA1 recombinant protein  >1 publications with CRYM and CRYBA1
 CRYBB1 recombinant protein  >1 publications with CRYM and CRYBB1

Pathways associated with CRYM recombinant protein

 Products by Pathway  Pathway Diagram
 Lysine Degradation II (pipecolate Pathway) antibodies  Lysine Degradation II (pipecolate Pathway) Diagram
 Lysine Degradation II (pipecolate Pathway) antibodies  Lysine Degradation II (pipecolate Pathway) Diagram
 Superpathway Of Lysine Degradation antibodies  Superpathway Of Lysine Degradation Diagram

Diseases associated with CRYM recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >9 publications with CRYM and Nervous System Diseases
 Disease Models, Animal Antibodies  >3 publications with CRYM and Disease Models, Animal
 Brain Diseases Antibodies  >2 publications with CRYM and Brain Diseases
 Infertility, Male Antibodies  >2 publications with CRYM and Infertility, Male
 Neoplasm Metastasis Antibodies  >1 publications with CRYM and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >1 publications with CRYM and Cardiovascular Diseases
 Weight Loss Antibodies  >1 publications with CRYM and Weight Loss
 Kidney Diseases Antibodies  >1 publications with CRYM and Kidney Diseases
 Necrosis Antibodies  >1 publications with CRYM and Necrosis

Organs/Tissues associated with CRYM recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with CRYM and Brain
 Heart Antibodies  >4 publications with CRYM and Heart
 Ear Antibodies  >4 publications with CRYM and Ear
 Muscle Antibodies  >4 publications with CRYM and Muscle
 Eye Antibodies  >3 publications with CRYM and Eye
 Blood Antibodies  >3 publications with CRYM and Blood
 Kidney Antibodies  >2 publications with CRYM and Kidney
 Lung Antibodies  >2 publications with CRYM and Lung
 Prostate Antibodies  >2 publications with CRYM and Prostate
 Testis Antibodies  >1 publications with CRYM and Testis
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