Serine/Threonine-Protein Kinase 24 (STK24) Antibody – Rabbit Polyclonal

This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

MST3: a protein kinase of the STE20 family. Activated by caspase-mediated cleavage

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; STE group; STE20 family; YSK subfamily

Chromosomal Location of Human Ortholog: 13q31.2-q32.3

Cellular Component: cytoplasm; cytosol; membrane; nucleolus; nucleoplasm; nucleus

Molecular Function: ATP binding; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding

Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase activity; apoptosis; cell migration; cell structure disassembly during apoptosis; induction of apoptosis by oxidative stress; negative regulation of cell migration; programmed cell death; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of axon regeneration; regulation of MAPKKK cascade; regulation of mitotic cell cycle; response to hydrogen peroxide; Rho protein signal transduction; signal transduction; stress-activated protein kinase signaling pathway