Periostin (POSTN) Antibody – Rabbit Polyclonal

This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

POSTN: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cell adhesion; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: extracellular matrix; extracellular space; neuromuscular junction; proteinaceous extracellular matrix; trans-Golgi network

Molecular Function: cell adhesion molecule binding; heparin binding; protein binding

Biological Process: cell adhesion; extracellular matrix organization and biogenesis; negative regulation of cell-matrix adhesion; positive regulation of smooth muscle cell migration; regulation of Notch signaling pathway; regulation of systemic arterial blood pressure; response to estradiol stimulus; response to hypoxia; response to mechanical stimulus; response to muscle activity; skeletal development