Endonuclease 8-Like 1 (NEIL1) Antibody – Rabbit Polyclonal

This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

NEIL1: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Belongs to the FPG family.

Protein type: DNA repair, damage; Hydrolase; EC 4.2.99.18; Lyase

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: chromosome; cytoplasm; microtubule organizing center; nucleoplasm; nucleus

Molecular Function: damaged DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; hydrolase activity, acting on glycosyl bonds; protein C-terminus binding; zinc ion binding

Biological Process: base-excision repair; base-excision repair, AP site formation; depyrimidination; DNA repair; negative regulation of nuclease activity; nucleotide-excision repair; response to oxidative stress