Rabbit Anti-MCL-1 Polyclonal Antibody – Cat# MBS1488748

Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog (MCL-1) Antibody – Rabbit Polyclonal

Name: MCL-1 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1488748
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1488748

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity. More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Polyclonal Antibody

Full Product Name

Rabbit anti-mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog polyclonal Antibody, Biotin conjugated

Product Gene Name

anti-Mcl-1 antibody

Product Synonym Names

Bcl-2-related protein EAT/mcl1; Mcl1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Purity/Purification

Caprylic Acid Ammonium Sulfate Precipitation Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: Mcl-1 (MBS1488301)
Biotin Conjugated Antibody: Mcl-1 (MBS1488748)

Molecular Weight

30,930 Da

3D Structure

ModBase 3D Structure for P97287

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Conjugate

Biotin

Immunogen

Recombinant mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog protein

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-Mcl-1 antibody

ELISA (EIA)

Other Notes

Small volumes of anti-Mcl-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mcl-1 purchase

MBS1488748 is an antibody targeting Mcl-1. Also known as Rabbit anti-mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog polyclonal Antibody, Biotin conjugated. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Mcl-1. It may not necessarily be applicable to this product.

NCBI GI #

6678824

NCBI GeneID

17210

NCBI Accession #

NP_032588.1

UniProt Primary Accession #

P97287

UniProt Secondary Accession #

Q3TUS0; Q792P0; Q9CRI4; D2K6L9

UniProt Related Accession #

P97287

GenBank Nucleotide #

NM_008562.3

NCBI Official Full Name

induced myeloid leukemia cell differentiation protein Mcl-1 homolog

NCBI Official Synonym Full Names

myeloid cell leukemia sequence 1

NCBI Official Symbol

Mcl1

NCBI Official Synonym Symbols

Mcl-1; AW556805

UniProt Protein Name

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

UniProt Synonym Protein Names

Bcl-2-related protein EAT/mcl1

Protein Family

Induced myeloid leukemia cell differentiation protein

UniProt Gene Name

Mcl1

UniProt Entry Name

MCL1_MOUSE

NCBI Protein Information

induced myeloid leukemia cell differentiation protein Mcl-1 homolog

UniProt Comments for Mcl-1

MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Protein type: Membrane protein, integral; Apoptosis; Channel, misc.; Mitochondrial; Inhibitor

Cellular Component: cytoplasm; cytosol; integral to membrane; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleus

Molecular Function: BH domain binding; BH3 domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity

Biological Process: apoptosis; apoptotic mitochondrial changes; cell differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; multicellular organismal development; negative regulation of apoptosis; regulation of apoptosis; response to cytokine stimulus

Research Articles on Mcl-1

1. Tax interacted with and activated TRAF6, and triggered its mitochondrial localization, where it conjugated four carboxyl-terminal lysine residues of MCL-1 with lysine 63-linked polyubiquitin chains

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Mcl-1 antibody

Reference Product	PubMed Publications
Bax antibody	>204 publications with Mcl-1 and Bax
Pmaip1 antibody	>53 publications with Mcl-1 and Pmaip1
Bak1 antibody	>44 publications with Mcl-1 and Bak1
Bid antibody	>35 publications with Mcl-1 and Bid
Trp53 antibody	>30 publications with Mcl-1 and Trp53
Bcl2l2 antibody	>16 publications with Mcl-1 and Bcl2l2
Usp9x antibody	>14 publications with Mcl-1 and Usp9x
Akt1 antibody	>10 publications with Mcl-1 and Akt1
Apaf1 antibody	>4 publications with Mcl-1 and Apaf1
Bcl2l11 antibody	>4 publications with Mcl-1 and Bcl2l11

Pathways associated with anti-Mcl-1 antibody

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
IL-7 Signaling Pathway antibodies	IL-7 Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
MicroRNAs In Cancer Pathway antibodies	MicroRNAs In Cancer Pathway Diagram
MicroRNAs In Cancer Pathway antibodies	MicroRNAs In Cancer Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-Mcl-1 antibody

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>69 publications with Mcl-1 and Lung Neoplasms
Lung Diseases Antibodies	>68 publications with Mcl-1 and Lung Diseases
Necrosis Antibodies	>55 publications with Mcl-1 and Necrosis
Breast Neoplasms Antibodies	>53 publications with Mcl-1 and Breast Neoplasms
Liver Diseases Antibodies	>46 publications with Mcl-1 and Liver Diseases
Multiple Myeloma Antibodies	>39 publications with Mcl-1 and Multiple Myeloma
Liver Neoplasms Antibodies	>36 publications with Mcl-1 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>34 publications with Mcl-1 and Carcinoma, Hepatocellular
Neoplasms, Experimental Antibodies	>33 publications with Mcl-1 and Neoplasms, Experimental
Inflammation Antibodies	>32 publications with Mcl-1 and Inflammation

Organs/Tissues associated with anti-Mcl-1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>176 publications with Mcl-1 and Blood
Lung Antibodies	>93 publications with Mcl-1 and Lung
Liver Antibodies	>79 publications with Mcl-1 and Liver
Bone Antibodies	>72 publications with Mcl-1 and Bone
Bone Marrow Antibodies	>56 publications with Mcl-1 and Bone Marrow
Brain Antibodies	>45 publications with Mcl-1 and Brain
Prostate Antibodies	>38 publications with Mcl-1 and Prostate
Skin Antibodies	>26 publications with Mcl-1 and Skin
Lymph Node Antibodies	>19 publications with Mcl-1 and Lymph Node
Kidney Antibodies	>15 publications with Mcl-1 and Kidney