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O-Phosphoseryl-Trna (SEPSECS) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1489626

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
O-phosphoseryl-tRNA (SEPSECS), Polyclonal Antibody
Full Product Name
Rabbit anti-human O-phosphoseryl-tRNA(Sec) selenium transferase polyclonal Antibody, FITC
Product Gene Name
anti-SEPSECS antibody
Product Synonym Names
Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2; ALDH1A2; RALDH2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: O-phosphoseryl-tRNA (Sec) selenium transferase (MBS7001020)
FITC Conjugated Antibody: O-phosphoseryl-tRNA (MBS1489626)
Molecular Weight
55,411 Da
OMIM
613009
3D Structure
ModBase 3D Structure for Q9HD40
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
FITC
Immunogen
Recombinant human O-phosphoseryl-tRNA(Sec) selenium transferase protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-131782 / sc-102105
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SEPSECS antibody
ELISA (EIA)

Other Notes

Small volumes of anti-SEPSECS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEPSECS purchase

MBS1489626 is an antibody targeting SEPSECS. Also known as Rabbit anti-human O-phosphoseryl-tRNA(Sec) selenium transferase polyclonal Antibody, FITC. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SEPSECS. It may not necessarily be applicable to this product.

NCBI GI #
267844904
NCBI GeneID
51091
NCBI Accession #
NP_058651.3
UniProt Primary Accession #
Q9HD40
UniProt Secondary Accession #
Q0D2P3; Q17RT1; Q9NXZ5; Q9UGM9; Q9Y353; A8K8W1
UniProt Related Accession #
Q9HD40
GenBank Nucleotide #
NM_016955.3
NCBI Official Full Name
O-phosphoseryl-tRNA(Sec) selenium transferase
NCBI Official Synonym Full Names
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
NCBI Official Symbol
SEPSECS
NCBI Official Synonym Symbols
LP; SLA; PCH2D; SLA/LP
UniProt Protein Name
O-phosphoseryl-tRNA(Sec) selenium transferase
UniProt Synonym Protein Names
Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein
Protein Family
O-phosphoseryl-tRNA(Sec) selenium transferase
UniProt Gene Name
SEPSECS
UniProt Synonym Gene Names
TRNP48; LP; Sec synthase; SepSecS; SLA
UniProt Entry Name
SPCS_HUMAN
NCBI Protein Information
O-phosphoseryl-tRNA(Sec) selenium transferase

NCBI Summary for SEPSECS

The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]
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UniProt Comments for SEPSECS

SLA/LP: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Defects in SEPSECS are the cause of pontocerebellar hypoplasia type 2D (PCH2D). PCH2D is a disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound mental retardation, spasticity, and variable seizures. Belongs to the SepSecS family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; EC 2.9.1.2; Transferase

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; tRNA binding

Biological Process: selenium metabolic process; selenocysteine incorporation; selenocysteine metabolic process

Disease: Pontocerebellar Hypoplasia, Type 2d
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Research Articles on SEPSECS

1. results suggest SEPSECS as a candidate gene for progressive encephalopathies with lactate elevation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SEPSECS antibody

 Reference Product  PubMed Publications
 PSTK antibody  >8 publications with SEPSECS and PSTK
 SEPHS1 antibody  >1 publications with SEPSECS and SEPHS1

Pathways associated with anti-SEPSECS antibody

 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
 Selenoamino Acid Metabolism Pathway antibodies  Selenoamino Acid Metabolism Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram
 Selenocysteine Synthesis Pathway antibodies  Selenocysteine Synthesis Pathway Diagram

Diseases associated with anti-SEPSECS antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >2 publications with SEPSECS and Mental Disorders
 Liver Diseases Antibodies  >2 publications with SEPSECS and Liver Diseases
 Necrosis Antibodies  >1 publications with SEPSECS and Necrosis

Organs/Tissues associated with anti-SEPSECS antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with SEPSECS and Brain
 Muscle Antibodies  >3 publications with SEPSECS and Muscle
 Liver Antibodies  >2 publications with SEPSECS and Liver
 Blood Antibodies  >2 publications with SEPSECS and Blood
 Placenta Antibodies  >1 publications with SEPSECS and Placenta
 Embryonic Tissue Antibodies  >1 publications with SEPSECS and Embryonic Tissue
 Kidney Antibodies  >1 publications with SEPSECS and Kidney
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