Transcription Initiation Factor IIB (IIB) Antibody – Rabbit Polyclonal

This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

GTF2B: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Associates with TFIID-IIA (DA complex) to form TFIID-IIA- IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1. Interacts with Epstein-Barr virus EBNA2. Belongs to the TFIIB family.

Protein type: Nuclear receptor co-regulator; Acetyltransferase; Transcription factor

Chromosomal Location of Human Ortholog: 1p22-p21

Cellular Component: nucleolus; nucleoplasm; nucleus

Molecular Function: protein binding; thyroid hormone receptor binding; transcription factor binding; zinc ion binding

Biological Process: gene expression; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction