TPM1 Antibody – Rabbit Polyclonal

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

Affinity Purification

Recombinant protein of human TPM1

Tropomyosin-1 (TPM1) belongs to the high molecular weight members of tropomyosin family. The protein exists in an alpha-helical coiled-coil conformation and binds multiple acting monomers in a tight manner to stabilize and regulate the actin filament. Tropomyosins fullfill functions in muscle and non-muscle cells. In muscle cells, tropomyosins associate with the troponin complex and play a central role in the calcium-dependent regulation of striated muscle contraction in vertebrates. In non-muscle cells, tropomyosins are implicated in the formation and stabilization of cytoskeletal actin filaments to ensure normal cellular processes. Mutations of tropomysin-1 have been reported as a cause of dilated cardiac myopathies. Tropomyosin-1 also functions as a tumor suppressor, and many malignant tumors demonstrate downregulation of tropomyosin-1 expression. Tropomyosin-1 is phosphorylated at Ser283 through the Erk/DAPK pathway, which promotes stress fiber formation in response to oxidative stress.

Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Manufactured in an ISO 9001:2015 Certified Laboratory.