Binding Protein (STAM) Antibody – Rabbit Polyclonal

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

AMSH: an adaptor protein involved in cytokine signal transduction the JAK-STAT cascade. Binds to the SH3 domain of the signal-transducing adaptor molecule STAM (signal transducing adaptor molecule). May play a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression.

Protein type: Protease; Ubiquitin-specific protease; EC 3.4.19.-; EC 3.1.2.15

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cleavage furrow; cytoplasm; early endosome; nucleoplasm; nucleus; plasma membrane

Molecular Function: metal ion binding; metallopeptidase activity; protein binding; protein domain specific binding; ubiquitin-specific protease activity

Biological Process: cytokinesis after mitosis; JAK-STAT cascade; negative regulation of neuron apoptosis; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of Ras protein signal transduction; positive regulation of cell proliferation; protein deubiquitination

Disease: Microcephaly-capillary Malformation Syndrome