Calcium-Dependent Phospholipase A2 (PLA2G5) Antibody – Rabbit Polyclonal

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

PLA2G5: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle. Defects in PLA2G5 are the cause of fleck retina, familial benign (FRFB). An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. Belongs to the phospholipase A2 family.

Protein type: EC 3.1.1.4; Secreted, signal peptide; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - alpha-linolenic acid; Secreted; Lipid Metabolism - linoleic acid; Lipid Metabolism - ether lipid; Cell surface; Phospholipase; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 1p36-p34

Cellular Component: cell surface; extracellular region; Golgi apparatus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: calcium ion binding; calcium-dependent phospholipase A2 activity; heparin binding

Biological Process: arachidonic acid secretion; glycerophospholipid biosynthetic process; leukotriene biosynthetic process; lipid catabolic process; phosphatidic acid biosynthetic process; phospholipid metabolic process; platelet activating factor biosynthetic process; response to cAMP; response to cytokine stimulus

Disease: Fleck Retina, Familial Benign