Urokinase Plasminogen Activator Surface Receptor (PLAU) Antibody – Rabbit Polyclonal

uPA: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. Defects in PLAU are the cause of Quebec platelet disorder (QPD). QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; EC 3.4.21.73; Secreted; Protease; Motility/polarity/chemotaxis

Cellular Component: cell surface; extracellular space; focal adhesion; membrane

Molecular Function: kinase activity; peptidase activity; serine-type endopeptidase activity

Biological Process: angiogenesis; embryo implantation; fibrinolysis; phosphorylation; positive regulation of cell proliferation; positive regulation of smooth muscle cell migration; proteolysis; regulation of cell adhesion mediated by integrin; regulation of cell proliferation; regulation of receptor activity; regulation of smooth muscle cell migration; response to activity; response to hyperoxia; response to hypoxia; skeletal muscle regeneration; smooth muscle cell migration; spermatogenesis; wound healing