Histone Deacetylase 4 (HDAC4) Antibody – Rabbit Polyclonal

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

HDAC4: a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Protein type: EC 3.5.1.98; Hydrolase; Deacetylase; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: A band; actomyosin; cytoplasm; cytosol; histone deacetylase complex; neuromuscular junction; nucleoplasm; nucleus; transcriptional repressor complex; Z disc

Molecular Function: chromatin binding; histone deacetylase activity; histone deacetylase binding; NAD-dependent histone deacetylase activity (H3-K14 specific); potassium ion binding; protein binding; protein deacetylase activity; protein kinase binding; sequence-specific DNA binding; transcription activator binding; transcription corepressor activity; transcription factor binding; zinc ion binding

Biological Process: B cell activation; B cell differentiation; cardiac muscle hypertrophy; chromatin remodeling; histone deacetylation; inflammatory response; negative regulation of cell proliferation; negative regulation of glycolysis; negative regulation of osteoblast differentiation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; osteoblast development; positive regulation of cell proliferation; positive regulation of neuron apoptosis; positive regulation of protein sumoylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression, epigenetic; regulation of protein binding; regulation of skeletal muscle fiber development; response to denervation involved in regulation of muscle adaptation; response to drug; skeletal development; transcription, DNA-dependent