Rabbit Anti-PTPN6 Polyclonal Antibody – Cat# MBS1490056

PTPN6 Antibody – Rabbit Polyclonal

Name: PTPN6 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1490056
Price: 420 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1490056

MBS1490056 is an antibody targeting PTPN6. Also known as Rabbit Anti Human PTPN6 PolyClonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PTPN6, Polyclonal Antibody

Full Product Name

Rabbit Anti Human PTPN6 PolyClonal Antibody

Product Gene Name

anti-PTPN6 antibody

Product Synonym Names

PTPN6; HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1; SH-PTP1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Affinity Purification

Molecular Weight

63,179 Da

Immunogen

Recombinant protein of human PTPN6

Relevance

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation. Because SHP-1 downregulates various proliferation pathways, SHP-1 is considered a potential tumor suppressor and angiogenesis regulator.

Storage Buffer

Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-PTPN6 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Other Notes

Small volumes of anti-PTPN6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPN6. It may not necessarily be applicable to this product.

NCBI GI #

2289910

NCBI GeneID

15170

NCBI Accession #

AAC36009.1

UniProt Secondary Accession #

O35128; Q63872; Q63873; Q63874; Q921G3; Q9QVA6; Q9QVA7; Q9QVA8; Q9R0V6

UniProt Related Accession #

P29351

NCBI Official Full Name

PTPN6

NCBI Official Synonym Full Names

protein tyrosine phosphatase, non-receptor type 6

NCBI Official Symbol

Ptpn6

NCBI Official Synonym Symbols

me; hcp; Hcph; Ptp1C; SHP-1; 70Z-SHP; SH-PTP1; PTPTY-42

UniProt Protein Name

Tyrosine-protein phosphatase non-receptor type 6

UniProt Synonym Protein Names

70Z-SHP; Hematopoietic cell protein-tyrosine phosphatase; PTPTY-42; Protein-tyrosine phosphatase 1C; PTP-1C; SH-PTP1; SHP-1

Protein Family

Tyrosine-protein phosphatase non-receptor

UniProt Gene Name

Ptpn6

UniProt Synonym Gene Names

Hcp; Hcph; Ptp1C; PTP-1C; SHP-1

UniProt Entry Name

PTN6_MOUSE

NCBI Protein Information

tyrosine-protein phosphatase non-receptor type 6; motheaten; protein-tyrosine phosphatase 1C; hematopoietic cell protein-tyrosine phosphatase

UniProt Comments for PTPN6

SHP-1: an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms have been described.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; nucleolus; alpha-beta T cell receptor complex; intercellular junction; intracellular; nucleus

Molecular Function: protein binding; hydrolase activity; phosphotyrosine binding; phosphoric monoester hydrolase activity; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; SH2 domain binding; protein kinase binding; phosphoprotein phosphatase activity; SH3 domain binding; natural killer cell lectin-like receptor binding

Biological Process: negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine phosphorylation; negative regulation of MAPKKK cascade; natural killer cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; negative regulation of T cell receptor signaling pathway; positive regulation of cell adhesion mediated by integrin; signal transduction; protein amino acid dephosphorylation; regulation of release of sequestered calcium ion into cytosol; positive regulation of phosphoinositide 3-kinase cascade; negative regulation of humoral immune response mediated by circulating immunoglobulin; cell proliferation; B cell receptor signaling pathway; negative regulation of T cell proliferation; dephosphorylation; negative regulation of B cell receptor signaling pathway; regulation of B cell differentiation; positive regulation of cell proliferation; abortive mitotic cell cycle; hemopoietic progenitor cell differentiation; platelet formation; cell differentiation

Research Articles on PTPN6

1. STAT3 was a substrate for SHP-1 by co-immunoprecipitation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PTPN6 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram

Diseases associated with anti-PTPN6 antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>126 publications with PTPN6 and Immune System Diseases
Inflammation Antibodies	>71 publications with PTPN6 and Inflammation
Death Antibodies	>57 publications with PTPN6 and Death
Necrosis Antibodies	>42 publications with PTPN6 and Necrosis
Nervous System Diseases Antibodies	>27 publications with PTPN6 and Nervous System Diseases
Cell Transformation, Neoplastic Antibodies	>26 publications with PTPN6 and Cell Transformation, Neoplastic
Liver Diseases Antibodies	>19 publications with PTPN6 and Liver Diseases
Liver Neoplasms Antibodies	>18 publications with PTPN6 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>17 publications with PTPN6 and Carcinoma, Hepatocellular
Breast Neoplasms Antibodies	>15 publications with PTPN6 and Breast Neoplasms

Organs/Tissues associated with anti-PTPN6 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>434 publications with PTPN6 and Blood
Bone Antibodies	>85 publications with PTPN6 and Bone
Bone Marrow Antibodies	>79 publications with PTPN6 and Bone Marrow
Liver Antibodies	>55 publications with PTPN6 and Liver
Brain Antibodies	>48 publications with PTPN6 and Brain
Spleen Antibodies	>36 publications with PTPN6 and Spleen
Kidney Antibodies	>33 publications with PTPN6 and Kidney
Lung Antibodies	>31 publications with PTPN6 and Lung
Skin Antibodies	>27 publications with PTPN6 and Skin
Embryonic Tissue Antibodies	>19 publications with PTPN6 and Embryonic Tissue