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Casein Kinase I Isoform Alpha (CK1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1490107

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in… More details

$230 / 0.05 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Casein kinase I isoform alpha (CK1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Casein kinase I isoform alpha polyclonal Antibody
Product Gene Name
anti-CK1 antibody
Product Synonym Names
Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1), CSNK1A1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%, Protein G purified
Preparation and Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: CK1 (MBS1490107)
FITC Conjugated Antibody: CK1 (MBS1489672)
Matching Pairs
Unconjugated Antibody: CK1 (MBS1490107)
HRP Conjugated Antibody: CK1 (MBS1490627)
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OMIM
600505
3D Structure
ModBase 3D Structure for P48729
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Species
Homo sapiens (Human)
Research Area
Signal Transduction
Target Names
CSNK1A1
Immunogen
Recombinant Human Casein kinase I isoform alpha protein (2-337AA)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6477 / sc-6478 / sc-28886
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CK1 antibody
ELISA, Immunohistochemistry (IHC)
Application Notes for anti-CK1 antibody
IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-CK1 antibody

Immunohistochemistry of paraffin-embedded human skin tissue using MBS1490107 at dilution 1:100
Rabbit Anti-CK1 Polyclonal Antibody – Cat# MBS1490107

Immunohistochemistry (IHC) of anti-CK1 antibody

Immunohistochemistry of paraffin-embedded human testis tissue using MBS1490107 at dilution 1:100
Rabbit Anti-CK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1490107

Other Notes

Small volumes of anti-CK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CK1 purchase

MBS1490107 is an antibody targeting CK1. Also known as Rabbit anti-human Casein kinase I isoform alpha polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CK1. It may not necessarily be applicable to this product.

NCBI GI #
68303575
NCBI GeneID
1452
NCBI Accession #
NP_001020276.1
UniProt Primary Accession #
P48729
UniProt Secondary Accession #
Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3; D3DQG0; D3DQG1
UniProt Related Accession #
P48729
GenBank Nucleotide #
NM_001025105.2
NCBI Official Full Name
casein kinase I isoform alpha isoform 1
NCBI Official Synonym Full Names
casein kinase 1 alpha 1
NCBI Official Symbol
CSNK1A1
NCBI Official Synonym Symbols
CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
UniProt Protein Name
Casein kinase I isoform alpha
UniProt Synonym Protein Names
CK1
Protein Family
Probable choline kinase
UniProt Gene Name
CSNK1A1
UniProt Synonym Gene Names
CKI-alpha
UniProt Entry Name
KC1A_HUMAN
NCBI Protein Information
casein kinase I isoform alpha

UniProt Comments for CK1

CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation.

Protein type: Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: beta-catenin destruction complex; centrosome; cytosol; keratin filament; membrane; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck; ribonucleoprotein complex

Molecular Function: ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: cell division; cell morphogenesis; cell surface receptor linked signal transduction; Golgi organization and biogenesis; intermediate filament cytoskeleton organization and biogenesis; mitosis; peptidyl-serine phosphorylation; phagocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; signal transduction; Wnt receptor signaling pathway
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Research Articles on CK1

1. The dynamical and conformational properties for each of three isoforms of CK1 are explored through molecular dynamics (MD) simulations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CK1 antibody

 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 Beta-catenin Phosphorylation Cascade Pathway antibodies  Beta-catenin Phosphorylation Cascade Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Degradation Of GLI2 By The Proteasome Pathway antibodies  Degradation Of GLI2 By The Proteasome Pathway Diagram
 Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies  Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
 Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway antibodies  Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway Diagram

Diseases associated with anti-CK1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with CK1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with CK1 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >1 publications with CK1 and Disease Models, Animal
 Cognition Disorders Antibodies  >1 publications with CK1 and Cognition Disorders
 Anemia Antibodies  >1 publications with CK1 and Anemia
 Hyperplasia Antibodies  >1 publications with CK1 and Hyperplasia
 Inflammation Antibodies  >1 publications with CK1 and Inflammation
 Leukemia-Lymphoma, Adult T-Cell Antibodies  >1 publications with CK1 and Leukemia-Lymphoma, Adult T-Cell

Organs/Tissues associated with anti-CK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with CK1 and Lung
 Bone Antibodies  >3 publications with CK1 and Bone
 Bone Marrow Antibodies  >2 publications with CK1 and Bone Marrow
 Blood Antibodies  >2 publications with CK1 and Blood
 Brain Antibodies  >2 publications with CK1 and Brain
 Lymph Node Antibodies  >1 publications with CK1 and Lymph Node
 Intestine Antibodies  >1 publications with CK1 and Intestine
 Skin Antibodies  >1 publications with CK1 and Skin
 Prostate Antibodies  >1 publications with CK1 and Prostate
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