Fractalkine (FKN) Antibody – Rabbit Polyclonal

CX3CL1: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: cell projection; cell surface; extracellular region; extracellular space; integral to membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: CCR chemokine receptor binding; chemokine activity; protein binding; receptor binding

Biological Process: aging; angiogenesis involved in wound healing; cell adhesion; chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; leukocyte adhesive activation; leukocyte chemotaxis; lymphocyte chemotaxis; macrophage chemotaxis; microglial cell activation; monocyte chemotaxis; negative regulation of cytokine secretion; negative regulation of vasoconstriction; neutrophil chemotaxis; platelet activation; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of neuroblast proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transforming growth factor-beta1 production; regulation of inhibitory postsynaptic membrane potential; response to hypoxia