G1/S-Specific Cyclin-D1 (CCND1) Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

CCND1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.

Protein type: Cell cycle regulation; Nuclear receptor co-regulator; Activator; Oncoprotein

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytosol; intracellular; membrane; nucleoplasm; nucleus; tight junction; transcriptional repressor complex

Molecular Function: cyclin-dependent protein kinase regulator activity; enzyme binding; histone deacetylase binding; protein binding; protein complex binding; protein kinase activity; protein kinase binding; transcription corepressor activity; transcription factor binding

Biological Process: cell division; establishment and/or maintenance of chromatin architecture; fat cell differentiation; G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; lactation; Leydig cell differentiation; liver development; mammary gland epithelial cell proliferation; mitotic cell cycle; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; Notch signaling pathway; organ regeneration; positive regulation of cyclin-dependent protein kinase activity; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; re-entry into mitotic cell cycle; response to calcium ion; response to corticosterone stimulus; response to DNA damage stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to iron ion; response to magnesium ion; response to organic nitrogen; response to vitamin E; response to X-ray; transcription, DNA-dependent; unfolded protein response; Wnt receptor signaling pathway through beta-catenin

Disease: Myeloma, Multiple; Von Hippel-lindau Syndrome