Fibroblast Growth Factor 1 (FGF1) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

FGF1: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: cell cortex; cytosol; extracellular region; extracellular space; nucleolus; nucleoplasm; proteinaceous extracellular matrix

Molecular Function: fibroblast growth factor receptor binding; growth factor activity; heparin binding; Hsp70 protein binding; protein binding

Biological Process: activation of MAPKK activity; anatomical structure morphogenesis; angiogenesis; axon guidance; cell proliferation; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; induction of an organ; innate immune response; insulin receptor signaling pathway; lung development; MAPKKK cascade; multicellular organismal development; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cholesterol biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of transcription from RNA polymerase II promoter; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway