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Muscarinic Acetylcholine Receptor M1 (M1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1490644

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi… More details

$230 / 0.05 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Muscarinic acetylcholine receptor M1, Polyclonal Antibody
Full Product Name
Rabbit anti-Rat Muscarinic acetylcholine receptor M1 polyclonal Antibody, FITC
Product Gene Name
anti-M1 antibody
Product Synonym Names
Chrm1; Chrm-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: M1 (MBS1491592)
FITC Conjugated Antibody: M1 (MBS1490644)
Molecular Weight
51,369 Da
3D Structure
ModBase 3D Structure for P08482
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
FITC
Immunogen
Recombinant Rat Muscarinic acetylcholine receptor M1 protein
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-M1 antibody
ELISA (EIA)

Other Notes

Small volumes of anti-M1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for M1 purchase

MBS1490644 is an antibody targeting M1. Also known as Rabbit anti-Rat Muscarinic acetylcholine receptor M1 polyclonal Antibody, FITC. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for M1. It may not necessarily be applicable to this product.

NCBI GI #
18249941
NCBI GeneID
25229
NCBI Accession #
NP_542951.1
UniProt Primary Accession #
P08482
UniProt Related Accession #
P08482
GenBank Nucleotide #
NM_080773.1
NCBI Official Full Name
muscarinic acetylcholine receptor M1
NCBI Official Synonym Full Names
cholinergic receptor, muscarinic 1
NCBI Official Symbol
Chrm1
UniProt Protein Name
Muscarinic acetylcholine receptor M1
Protein Family
Germanicol synthase
UniProt Gene Name
Chrm1
UniProt Synonym Gene Names
Chrm-1
UniProt Entry Name
ACM1_RAT
NCBI Protein Information
muscarinic acetylcholine receptor M1

NCBI Summary for M1

plays a role in acetylcholine receptor signaling and neuromuscular synaptic transmission [RGD, Feb 2006]

UniProt Comments for M1

mAChR m1: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: asymmetric synapse; cell junction; dendrite; integral to plasma membrane; nerve terminal; plasma membrane; postsynaptic density; postsynaptic membrane; synapse

Molecular Function: drug binding; G-protein coupled acetylcholine receptor activity

Biological Process: acetylcholine receptor signaling, muscarinic pathway; cognition; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; neuromuscular synaptic transmission; positive regulation of ion transport; regulation of locomotion; regulation of vascular smooth muscle contraction; saliva secretion; synaptic transmission, cholinergic
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Research Articles on M1

1. Neonatal hypoglycemia decreased total muscarinic receptors (p < 0.001) with reduced muscarinic M1, M2, and M3 receptor genes (p < 0.001) in one month old rats.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-M1 antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-M1 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >21 publications with M1 and Mental Disorders
 Nervous System Diseases Antibodies  >6 publications with M1 and Nervous System Diseases
 Depressive Disorder Antibodies  >4 publications with M1 and Depressive Disorder
 Cognition Disorders Antibodies  >4 publications with M1 and Cognition Disorders
 Neurodegenerative Diseases Antibodies  >4 publications with M1 and Neurodegenerative Diseases
 Inflammation Antibodies  >3 publications with M1 and Inflammation
 Poisoning Antibodies  >2 publications with M1 and Poisoning
 Movement Disorders Antibodies  >1 publications with M1 and Movement Disorders
 Drug-Induced Liver Injury Antibodies  >1 publications with M1 and Drug-Induced Liver Injury
 Necrosis Antibodies  >1 publications with M1 and Necrosis
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