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NADPH Oxidase 4 (NOX4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1490653

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NADPH oxidase 4 (Nox4), Polyclonal Antibody
Full Product Name
Rabbit anti-rat NADPH oxidase 4 polyclonal Antibody
Product Gene Name
anti-Nox4 antibody
Product Synonym Names
Kidney oxidase-1 Kidney superoxide-producing NADPH oxidase Nox4 Kox
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: NADPH oxidase 4 (MBS1490653)
HRP Conjugated Antibody: NADPH oxidase 4 (MBS1488668)
Matching Pairs
Unconjugated Antibody: NADPH oxidase 4 (MBS1490653)
FITC Conjugated Antibody: NADPH oxidase 4 (MBS1491294)
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Molecular Weight
66,469 Da
3D Structure
ModBase 3D Structure for Q924V1
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant rat NADPH oxidase 4 protein
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-Nox4 antibody
ELISA (EIA)

Western Blot (WB) of anti-Nox4 antibody

Western Blot
Positive WB detected in: U251 whole cell lysate, SH-SY5Y whole cell lysate
All lanes: Nox4 antibody at 3.3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 67 KDa
Observed band size: 67 KDa
Rabbit Anti-NOX4 Polyclonal Antibody – Cat# MBS1490653

Other Notes

Small volumes of anti-Nox4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nox4 purchase

MBS1490653 is an antibody targeting Nox4. Also known as Rabbit anti-rat NADPH oxidase 4 polyclonal Antibody. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Nox4. It may not necessarily be applicable to this product.

NCBI GI #
16758288
NCBI GeneID
85431
NCBI Accession #
NP_445976.1
UniProt Primary Accession #
Q924V1
UniProt Secondary Accession #
Q99M78
UniProt Related Accession #
Q924V1
GenBank Nucleotide #
NM_053524.1
NCBI Official Full Name
NADPH oxidase 4
NCBI Official Synonym Full Names
NADPH oxidase 4
NCBI Official Symbol
Nox4
UniProt Protein Name
NADPH oxidase 4
UniProt Synonym Protein Names
Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase
Protein Family
NADPH oxidase
UniProt Gene Name
Nox4
UniProt Synonym Gene Names
Kox; KOX-1
UniProt Entry Name
NOX4_RAT
NCBI Protein Information
NADPH oxidase 4

NCBI Summary for Nox4

enzyme involved in the production of reactive oxygen species in vascular smooth muscle cells [RGD, Feb 2006]

UniProt Comments for Nox4

NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Cell cycle regulation; Oxidoreductase; Membrane protein, multi-pass; EC 1.6.3.-; Membrane protein, integral
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Research Articles on Nox4

1. Glycated albumin increases the permissiveness of proximal tubular cells to fibrosis and apoptosis in vitro by triggering a pathway that involves Nox4.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Nox4 antibody

 Reference Product  PubMed Publications
 Nox1 antibody  >357 publications with Nox4 and Nox1
 Cyba antibody  >61 publications with Nox4 and Cyba
 Noxa1 antibody  >20 publications with Nox4 and Noxa1
 Ncf1 antibody  >3 publications with Nox4 and Ncf1
 Agt antibody  >2 publications with Nox4 and Agt
 Uqcrfs1 antibody  >1 publications with Nox4 and Uqcrfs1

Pathways associated with anti-Nox4 antibody

 Products by Pathway  Pathway Diagram
 PKC-SCP2 Pathway antibodies  PKC-SCP2 Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with anti-Nox4 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >200 publications with Nox4 and Inflammation
 Hypertension Antibodies  >200 publications with Nox4 and Hypertension
 Fibrosis Antibodies  >171 publications with Nox4 and Fibrosis
 Disease Models, Animal Antibodies  >168 publications with Nox4 and Disease Models, Animal
 Heart Diseases Antibodies  >135 publications with Nox4 and Heart Diseases
 Atherosclerosis Antibodies  >113 publications with Nox4 and Atherosclerosis
 Hypertrophy Antibodies  >105 publications with Nox4 and Hypertrophy
 Kidney Diseases Antibodies  >104 publications with Nox4 and Kidney Diseases
 Necrosis Antibodies  >79 publications with Nox4 and Necrosis
 Lung Diseases Antibodies  >73 publications with Nox4 and Lung Diseases

Organs/Tissues associated with anti-Nox4 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >225 publications with Nox4 and Kidney
 Mixed Antibodies  >4 publications with Nox4 and Mixed
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