Lysine-Specific Demethylase 5a (KDM5A) Antibody – Rabbit Polyclonal

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

JARID1A: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Interacts with SUZ12; the interaction is direct. Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Oxidoreductase; Nucleolus; EC 1.14.11.-; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 12p11

Cellular Component: cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; nucleolus; nucleoplasm; nucleus

Molecular Function: chromatin DNA binding; DNA binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein binding; transcription coactivator activity; transcription factor activity; zinc ion binding

Biological Process: circadian regulation of gene expression; establishment and/or maintenance of chromatin architecture; male gonad development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; spermatogenesis; transcription from RNA polymerase II promoter