Very Long-Chain Acyl-Coa Synthetase (CoA) Antibody – Rabbit Polyclonal

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

SLC27A5: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Lipid Metabolism - primary bile acid biosynthesis; Membrane protein, multi-pass; Membrane protein, integral; EC 6.2.1.7; Endoplasmic reticulum; Ligase

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: basal plasma membrane; endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; protein complex

Molecular Function: ATP binding; cholate-CoA ligase activity; fatty acid transporter activity; long-chain-fatty-acid-CoA ligase activity; protein complex binding; very-long-chain-fatty-acid-CoA ligase activity

Biological Process: bile acid and bile salt transport; bile acid biosynthetic process; bile acid metabolic process; ketone body biosynthetic process; long-chain fatty acid metabolic process; plasma membrane long-chain fatty acid transport; triacylglycerol mobilization; very-long-chain fatty acid metabolic process