High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma (FCER1G) Antibody – Rabbit Polyclonal

FCER1G: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. Belongs to the CD3Z/FCER1G family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: cell surface; external side of plasma membrane; Fc-epsilon receptor I complex; integral to plasma membrane; plasma membrane

Molecular Function: IgE binding; IgE receptor activity; IgG binding; protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; defense response to bacterium; Fc receptor mediated stimulatory signaling pathway; immunoglobulin mediated immune response; innate immune response; integrin-mediated signaling pathway; leukocyte migration; mast cell activation; negative regulation of mast cell apoptosis; neutrophil activation during immune response; neutrophil chemotaxis; phagocytosis, engulfment; platelet activation; positive regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of mast cell cytokine production; positive regulation of mast cell degranulation; positive regulation of phagocytosis; positive regulation of tumor necrosis factor production; positive regulation of type I hypersensitivity; positive regulation of type IIa hypersensitivity; positive regulation of type III hypersensitivity; receptor internalization; serotonin secretion by platelet; stimulatory C-type lectin receptor signaling pathway; T cell differentiation during immune response