D-Beta-Hydroxybutyrate Dehydrogenase (BDH1) Antibody – Rabbit Polyclonal

This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

BDH: a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Protein type: Mitochondrial; Carbohydrate Metabolism - butanoate; EC 1.1.1.30; Oxidoreductase; Lipid Metabolism - synthesis and degradation of ketone bodies

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; nucleoplasm

Molecular Function: 3-hydroxybutyrate dehydrogenase activity; phospholipid binding

Biological Process: brain development; cellular lipid metabolic process; ketone body biosynthetic process; ketone body catabolic process; ketone body metabolic process; liver development; response to cadmium ion; response to corticosterone stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to insulin stimulus; response to nutrient; response to starvation; response to toxin