MED30 Antibody – Rabbit Polyclonal

MED30: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 30 family.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 8q24.11

Cellular Component: nucleoplasm; nucleus; Srb-mediator complex; ubiquitin ligase complex

Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; protein binding; receptor activity; thyroid hormone receptor binding; transcription cofactor activity; vitamin D receptor binding

Biological Process: androgen receptor signaling pathway; gene expression; positive regulation of transcription, DNA-dependent; protein ubiquitination; regulation of transcription from RNA polymerase II promoter; stem cell maintenance; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter