UGT2B4 Antibody – Rabbit Polyclonal

UGT2B4: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid. Belongs to the UDP-glycosyltransferase family.

Protein type: EC 2.4.1.17; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - ascorbate and aldarate; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Lipid Metabolism - androgen and estrogen; Cofactor and Vitamin Metabolism - retinol; Transferase; Carbohydrate Metabolism - pentose and glucuronate interconversions; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle

Molecular Function: glucuronosyltransferase activity; retinoic acid binding

Biological Process: estrogen catabolic process; flavonoid biosynthetic process; metabolic process; xenobiotic metabolic process