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DSTN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1492033

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DSTN, Polyclonal Antibody
Full Product Name
DSTN Antibody
Product Gene Name
anti-DSTN antibody
Product Synonym Names
Destrin; DSTN; ACTDP; DSN; Actin-depolymerizing factor; ADF
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: DSTN (MBS1492033)
Biotin Conjugated Antibody: DSTN (MBS1492774)
Matching Pairs
Unconjugated Antibody: DSTN (MBS1492033)
HRP Conjugated Antibody: DSTN (MBS1497132)
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Molecular Weight
16,621 Da
OMIM
609114
3D Structure
ModBase 3D Structure for P60981
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Destrin protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22544 / sc-22546
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DSTN antibody
ELISA (EIA), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-DSTN antibody

Immunohistochemistry of paraffin-embedded human prostate cancer using MBS1492033 at dilution of 1:100
Rabbit Anti-DSTN Polyclonal Antibody – Cat# MBS1492033

Immunohistochemistry (IHC) of anti-DSTN antibody

Immunohistochemistry of paraffin-embedded human bladder tissue using MBS1492033 at dilution of 1:100
Rabbit Anti-DSTN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1492033

Other Notes

Small volumes of anti-DSTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DSTN purchase

MBS1492033 is an antibody targeting DSTN. Also known as DSTN Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DSTN. It may not necessarily be applicable to this product.

NCBI GI #
58530848
NCBI GeneID
11034
NCBI Accession #
NP_001011546.1
UniProt Primary Accession #
P60981
UniProt Secondary Accession #
P18282; Q5W166; Q6IAW2; B2R6N2; B4DYA6
UniProt Related Accession #
P60981
GenBank Nucleotide #
NM_001011546.1
NCBI Official Full Name
destrin isoform b
NCBI Official Synonym Full Names
destrin (actin depolymerizing factor)
NCBI Official Symbol
DSTN
NCBI Official Synonym Symbols
ADF; ACTDP; HEL32; bA462D18.2
UniProt Protein Name
Destrin
UniProt Synonym Protein Names
Actin-depolymerizing factor; ADF
Protein Family
Destrin
UniProt Gene Name
DSTN
UniProt Synonym Gene Names
ACTDP; DSN; ADF
UniProt Entry Name
DEST_HUMAN
NCBI Protein Information
destrin

NCBI Summary for DSTN

The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for DSTN

Destrin: an actin-depolymerizing cytoskeletal protein that belongs to the ADF actin-binding protein family. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Present in many vertebrate tissues and particularly abundant in neuronal cells. It binds F-actin in a pH-dependent manner which affects it's severing/depolymerizing activities. It also binds G-actin at pH 8.0 thereby sequestering monomers and preventing polymerization.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20p12.1

Cellular Component: actin cytoskeleton; cortical actin cytoskeleton

Molecular Function: actin binding; protein binding

Biological Process: actin filament depolymerization; actin filament severing; actin polymerization and/or depolymerization; positive regulation of actin filament depolymerization
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Research Articles on DSTN

1. Destrin is upregulated in nerve-invasive pancreatic cancer cells and its expression might be related to perineural invasiveness

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DSTN antibody

 Reference Product  PubMed Publications
 WDR1 antibody  >2 publications with DSTN and WDR1
 CAP1 antibody  >1 publications with DSTN and CAP1
 CAP2 antibody  >1 publications with DSTN and CAP2

Pathways associated with anti-DSTN antibody

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram

Diseases associated with anti-DSTN antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with DSTN and Inflammation
 Neoplasm Metastasis Antibodies  >3 publications with DSTN and Neoplasm Metastasis
 Prostatic Diseases Antibodies  >2 publications with DSTN and Prostatic Diseases
 Neoplasms, Experimental Antibodies  >2 publications with DSTN and Neoplasms, Experimental
 Kidney Diseases Antibodies  >2 publications with DSTN and Kidney Diseases
 Embryo Loss Antibodies  >2 publications with DSTN and Embryo Loss
 Prostatic Neoplasms Antibodies  >2 publications with DSTN and Prostatic Neoplasms
 Urogenital Abnormalities Antibodies  >1 publications with DSTN and Urogenital Abnormalities
 Infertility, Female Antibodies  >1 publications with DSTN and Infertility, Female
 Infertility, Male Antibodies  >1 publications with DSTN and Infertility, Male

Organs/Tissues associated with anti-DSTN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with DSTN and Brain
 Nerve Antibodies  >11 publications with DSTN and Nerve
 Muscle Antibodies  >8 publications with DSTN and Muscle
 Eye Antibodies  >7 publications with DSTN and Eye
 Kidney Antibodies  >4 publications with DSTN and Kidney
 Embryonic Tissue Antibodies  >4 publications with DSTN and Embryonic Tissue
 Testis Antibodies  >3 publications with DSTN and Testis
 Bone Antibodies  >3 publications with DSTN and Bone
 Skin Antibodies  >2 publications with DSTN and Skin
 Prostate Antibodies  >2 publications with DSTN and Prostate
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