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HSPA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1492068

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through… More details

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Product Overview

Online Datasheet in PDF
Product Name
HSPA2, Polyclonal Antibody
Full Product Name
HSPA2 Antibody
Product Gene Name
anti-HSPA2 antibody
Product Synonym Names
Heat shock 70 kDa protein 2; HSPA2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
70,021 Da
OMIM
140560
3D Structure
ModBase 3D Structure for P54652
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Heat shock-related 70 kDa protein 2 protein (400-639aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-160010
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-HSPA2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-HSPA2 antibody
Recommended dilution: WB:1:500-5000
IHC:1:20-1:200

Western Blot (WB) of anti-HSPA2 antibody

Western blot
All lanes: HSPA2 antibody at 6ug/ml
Lane 1:A431 whole cell lysate
Lane 2:Hela whole cell lysate
Lane 3:Rat brain tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 70kDa
Observed band size: 70kDa
Rabbit Anti-HSPA2 Polyclonal Antibody – Cat# MBS1492068

Immunohistochemistry (IHC) of anti-HSPA2 antibody

Immunohistochemistry of paraffin-embedded human testis using MBS1492068 at dilution 1:100
Rabbit Anti-HSPA2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1492068

Immunoprecipitation (IP) of anti-HSPA2 antibody

Immunoprecipitating HSPA2 in Hela whole cell lysate
Lane 1: Rabbit monoclonal IgG(1ug)instead of MBS1492068 in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: MBS1492068(4ug)+ Hela whole cell lysate(500ug)
Lane 3: Hela whole cell lysate (20ug)
Rabbit Anti-HSPA2 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS1492068

Other Notes

Small volumes of anti-HSPA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSPA2 purchase

MBS1492068 is an antibody targeting HSPA2. Also known as HSPA2 Antibody. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPA2. It may not necessarily be applicable to this product.

NCBI GI #
13676857
NCBI GeneID
3306
NCBI Accession #
NP_068814.2
UniProt Primary Accession #
P54652
UniProt Secondary Accession #
Q15508; Q53XM3; Q9UE78
UniProt Related Accession #
P54652
GenBank Nucleotide #
NM_021979.3
NCBI Official Full Name
heat shock-related 70 kDa protein 2
NCBI Official Synonym Full Names
heat shock protein family A (Hsp70) member 2
NCBI Official Symbol
HSPA2
NCBI Official Synonym Symbols
HSP70-2; HSP70-3
UniProt Protein Name
Heat shock-related 70 kDa protein 2
Protein Family
Heat shock-related 70 kDa protein
UniProt Gene Name
HSPA2
UniProt Synonym Gene Names
Heat shock 70 kDa protein 2
UniProt Entry Name
HSP72_HUMAN
NCBI Protein Information
heat shock-related 70 kDa protein 2

UniProt Comments for HSPA2

HSPA2: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Interacts with ZNF541. Component of the CatSper complex. Belongs to the heat shock protein 70 family.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: cell surface; cytosol; male germ cell nucleus; membrane; mitochondrion; myelin sheath; nucleus; synaptonemal complex

Molecular Function: ATP binding; enzyme binding; glycolipid binding; protein binding; unfolded protein binding

Biological Process: G2/M-specific positive regulation of cyclin-dependent protein kinase activity; male meiosis; male meiosis I; protein refolding; response to cold; response to heat; response to unfolded protein; spermatid development; spermatogenesis
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Research Articles on HSPA2

1. HSPA2 expression increased under conditions that stimulated HIF-1alpha activity, whereas inhibition of HIF-1alpha abrogated hypoxia-induced up-regulation of HSPA2 expression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSPA2 antibody

 Reference Product  PubMed Publications
 HSP90AA1 antibody  >2 publications with HSPA2 and HSP90AA1
 DNAJB1 antibody  >2 publications with HSPA2 and DNAJB1
 DNAJB6 antibody  >1 publications with HSPA2 and DNAJB6

Pathways associated with anti-HSPA2 antibody

 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram

Diseases associated with anti-HSPA2 antibody

 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >32 publications with HSPA2 and Infertility, Male
 Necrosis Antibodies  >11 publications with HSPA2 and Necrosis
 Adenocarcinoma Antibodies  >8 publications with HSPA2 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >6 publications with HSPA2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >5 publications with HSPA2 and Liver Diseases
 Liver Neoplasms Antibodies  >5 publications with HSPA2 and Liver Neoplasms
 Nervous System Diseases Antibodies  >5 publications with HSPA2 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with HSPA2 and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >4 publications with HSPA2 and Lung Neoplasms
 Inflammation Antibodies  >4 publications with HSPA2 and Inflammation

Organs/Tissues associated with anti-HSPA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >57 publications with HSPA2 and Testis
 Blood Antibodies  >16 publications with HSPA2 and Blood
 Brain Antibodies  >10 publications with HSPA2 and Brain
 Muscle Antibodies  >8 publications with HSPA2 and Muscle
 Liver Antibodies  >8 publications with HSPA2 and Liver
 Prostate Antibodies  >7 publications with HSPA2 and Prostate
 Lung Antibodies  >6 publications with HSPA2 and Lung
 Kidney Antibodies  >5 publications with HSPA2 and Kidney
 Esophagus Antibodies  >3 publications with HSPA2 and Esophagus
 Intestine Antibodies  >3 publications with HSPA2 and Intestine
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