• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Glutaredoxin-3 (GLRX3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1492222

Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glutaredoxin-3 (GLRX3), Polyclonal Antibody
Full Product Name
Rabbit anti-human Glutaredoxin-3 polyclonal Antibody(GLRX3)
Product Gene Name
Product Synonym Names
PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2; GLRX3; PICOT; TXNL2; HUSSY-22
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
37,432 Da
OMIM
612754
3D Structure
ModBase 3D Structure for O76003
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Glutaredoxin-3 protein (1-335aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-69309 / sc-69306 / sc-69308
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GLRX3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-GLRX3 antibody
Recommended dilution: WB:1:500-5000
IHC:1:20-1:200

Western Blot (WB) of anti-GLRX3 antibody

All lanes: Glutaredoxin-3 antibody at 10ug/ml
Lane 1:rat brain tissue
Lane 2:HepG2 whole cell lysate
Lane 3:Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 37kDa
Observed band size: 37kDa
Rabbit Anti-GLRX3 Polyclonal Antibody – Cat# MBS1492222

Immunohistochemistry (IHC) of anti-GLRX3 antibody

Immunohistochemistry of paraffin-embedded human testicle using MBS1492222 at dilution 1:100
Rabbit Anti-GLRX3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1492222

Immunohistochemistry (IHC) of anti-GLRX3 antibody

Immunohistochemistry of paraffin-embedded human colon cancer using MBS1492222 at dilution 1:100
Rabbit Anti-GLRX3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1492222

Immunoprecipitation (IP) of anti-GLRX3 antibody

Immunoprecipitating GLRX3 in HepG2 whole cell lysate
Lane 1: Rabbit monoclonal IgG(1ug)instead of MBS1492222 in HepG2 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: MBS1492222(4ug)+ HepG2 whole cell lysate(500ug)
Lane 3: HepG2 whole cell lysate (20ug)
Rabbit Anti-GLRX3 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS1492222

Other Notes

Small volumes of anti-GLRX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLRX3 purchase

MBS1492222 is an antibody targeting GLRX3. Also known as Rabbit anti-human Glutaredoxin-3 polyclonal Antibody(GLRX3). Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GLRX3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
glutaredoxin-3
NCBI Official Synonym Full Names
glutaredoxin 3
NCBI Official Symbol
GLRX3
NCBI Official Synonym Symbols
GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3
UniProt Protein Name
Glutaredoxin-3
UniProt Synonym Protein Names
PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2
Protein Family
UniProt Gene Name
GLRX3
UniProt Synonym Gene Names
PICOT; TXNL2; PICOT; PKCq-interacting protein
UniProt Entry Name
GLRX3_HUMAN
NCBI Protein Information
glutaredoxin-3

NCBI Summary for GLRX3

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Show more

UniProt Comments for GLRX3

GLRX3: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: cell cortex; dendrite; nucleus; Z disc

Molecular Function: electron carrier activity; iron-sulfur cluster binding; metal ion binding; protein binding; protein disulfide oxidoreductase activity; protein kinase C binding

Biological Process: cell redox homeostasis; regulation of the force of heart contraction
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000