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Trimethylguanosine Synthase (TGS1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1492260

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Trimethylguanosine synthase (TGS1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Trimethylguanosine synthase polyclonal Antibody(TGS1), FITC
Product Gene Name
anti-TGS1 antibody
Product Synonym Names
CLL-associated antigen KW-2; Cap-specific guanine-N2 methyltransferase; Hepatocellular carcinoma-associated antigen 137; Nuclear receptor coactivator 6-interacting protein; PRIP-interacting protein with methyltransferase motif; PIMT; PIPMT; HCA137; NCOA6IP; PIMT; TGS1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: Trimethylguanosine synthase (MBS7000702)
FITC Conjugated Antibody: TGS1 (MBS1492260)
Molecular Weight
96,620 Da
OMIM
606461
3D Structure
ModBase 3D Structure for Q96RS0
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
FITC
Immunogen
Recombinant human Trimethylguanosine synthase protein(713-853AA)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23113 / sc-23114
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TGS1 antibody
ELISA (EIA)

Other Notes

Small volumes of anti-TGS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGS1 purchase

MBS1492260 is an antibody targeting TGS1. Also known as Rabbit anti-human Trimethylguanosine synthase polyclonal Antibody(TGS1), FITC. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TGS1. It may not necessarily be applicable to this product.

NCBI GI #
151301096
NCBI GeneID
96764
NCBI Accession #
NP_079107.6
UniProt Primary Accession #
Q96RS0
UniProt Secondary Accession #
Q5GH23; Q8TDG9; Q96QU3; Q9H5V3; A6NJQ5
UniProt Related Accession #
Q96RS0
GenBank Nucleotide #
NM_024831.7
NCBI Official Full Name
trimethylguanosine synthase isoform 1
NCBI Official Synonym Full Names
trimethylguanosine synthase 1
NCBI Official Symbol
TGS1
NCBI Official Synonym Symbols
PIMT; PIPMT; NCOA6IP
UniProt Protein Name
Trimethylguanosine synthase
UniProt Synonym Protein Names
CLL-associated antigen KW-2; Cap-specific guanine-N2 methyltransferase; Hepatocellular carcinoma-associated antigen 137; Nuclear receptor coactivator 6-interacting protein; PRIP-interacting protein with methyltransferase motif; PIMT; PIPMT
Protein Family
Probable diacyglycerol O-acyltransferase
UniProt Gene Name
TGS1
UniProt Synonym Gene Names
HCA137; NCOA6IP; PIMT; PIMT; PIPMT
UniProt Entry Name
TGS1_HUMAN
NCBI Protein Information
trimethylguanosine synthase

UniProt Comments for TGS1

PIMT: a nuclear protein and apparent methyltransferase. Binds S-adenosyl-L-methionine and RNA. Plays a role in transcriptional regulation. Interacts with NCOA, CBP, p300, and PPARBP. Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.

Protein type: RNA processing; EC 2.1.1.-; Nuclear receptor co-regulator; Methyltransferase

Chromosomal Location of Human Ortholog: 8q11

Cellular Component: Cajal body; cytoplasm; cytosol; extracellular space; nucleolus; nucleoplasm; nucleus; small nuclear ribonucleoprotein complex

Molecular Function: protein binding

Biological Process: cellular lipid metabolic process; gene expression; regulation of transcription, DNA-dependent; ribonucleoprotein complex biogenesis and assembly; RNA capping; spliceosomal snRNP biogenesis; transcription, DNA-dependent
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Research Articles on TGS1

1. PIMT was identified as a key player responsible for glycated low density lipoproteins induced vascular endothelial cell apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TGS1 antibody

 Reference Product  PubMed Publications
 SNUPN antibody  >1 publications with TGS1 and SNUPN
 NCOA6 antibody  >1 publications with TGS1 and NCOA6

Pathways associated with anti-TGS1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Non-coding RNA Pathway antibodies  Metabolism Of Non-coding RNA Pathway Diagram

Diseases associated with anti-TGS1 antibody

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >1 publications with TGS1 and Atrophy

Organs/Tissues associated with anti-TGS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >1 publications with TGS1 and Uterus
 Testis Antibodies  >1 publications with TGS1 and Testis
 Blood Antibodies  >1 publications with TGS1 and Blood
 Muscle Antibodies  >1 publications with TGS1 and Muscle
 Brain Antibodies  >1 publications with TGS1 and Brain
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