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Endothelin-Converting Enzyme 2 (ECE2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1492278

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Endothelin-converting enzyme 2 (ECE2), Polyclonal Antibody
Full Product Name
Rabbit anti-human Endothelin-converting enzyme 2 polyclonal Antibody(ECE2)
Product Gene Name
anti-ECE2 antibody
Product Synonym Names
ECE-2; ECE2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
91,211 Da
OMIM
610145
3D Structure
ModBase 3D Structure for O60344
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Endothelin-converting enzyme 2 protein(1-160aa)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ECE2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ECE2 antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-ECE2 antibody

Immunohistochemistry of paraffin-embedded human rectum using MBS1492278 at dilution 1:100
Rabbit Anti-ECE2 Polyclonal Antibody – Cat# MBS1492278

Immunohistochemistry (IHC) of anti-ECE2 antibody

Immunohistochemistry of paraffin-embedded human brain using MBS1492278 at dilution 1:100
Rabbit Anti-ECE2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1492278

Other Notes

Small volumes of anti-ECE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ECE2 purchase

MBS1492278 is an antibody targeting ECE2. Also known as Rabbit anti-human Endothelin-converting enzyme 2 polyclonal Antibody(ECE2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ECE2. It may not necessarily be applicable to this product.

NCBI GI #
82617560
NCBI GeneID
9718
NCBI Accession #
NP_001032401.1
UniProt Primary Accession #
O60344
UniProt Secondary Accession #
Q6NTG7; Q6UW36; Q8NFD7; Q96NX3; Q96NX4; Q9BRZ8; A5PLK8
UniProt Related Accession #
O60344
GenBank Nucleotide #
NM_001037324.2
NCBI Official Full Name
endothelin-converting enzyme 2 isoform B
NCBI Official Synonym Full Names
endothelin converting enzyme 2
NCBI Official Symbol
ECE2
UniProt Protein Name
Endothelin-converting enzyme 2
Protein Family
Endothelin-converting enzyme
UniProt Gene Name
ECE2
UniProt Synonym Gene Names
KIAA0604; ECE-2
UniProt Entry Name
ECE2_HUMAN
NCBI Protein Information
endothelin-converting enzyme 2

NCBI Summary for ECE2

This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for ECE2

ECE2: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; Protease; Vesicle; Methyltransferase, protein arginine, predicted; Membrane protein, integral; EC 3.4.24.71

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: cytoplasmic vesicle membrane; Golgi membrane; integral to membrane

Molecular Function: metal ion binding; metalloendopeptidase activity; methyltransferase activity; protein binding

Biological Process: brain development; cardioblast differentiation; cell-cell signaling; heart development; methylation; peptide hormone processing
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Research Articles on ECE2

1. Te results of this study suggested taht genetic variations in MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9 genes do not play major role among the Finnish AD patient cohort.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ECE2 antibody

 Reference Product  PubMed Publications
 EDN1 antibody  >5 publications with ECE2 and EDN1
 EDN2 antibody  >4 publications with ECE2 and EDN2
 EDNRA antibody  >3 publications with ECE2 and EDNRA
 EDNRB antibody  >3 publications with ECE2 and EDNRB
 EDN3 antibody  >2 publications with ECE2 and EDN3

Diseases associated with anti-ECE2 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4 publications with ECE2 and Brain Diseases
 Nervous System Diseases Antibodies  >3 publications with ECE2 and Nervous System Diseases
 Inflammation Antibodies  >2 publications with ECE2 and Inflammation
 Cardiovascular Diseases Antibodies  >1 publications with ECE2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >1 publications with ECE2 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with ECE2 and Adenocarcinoma
 Lung Diseases Antibodies  >1 publications with ECE2 and Lung Diseases

Organs/Tissues associated with anti-ECE2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with ECE2 and Brain
 Liver Antibodies  >3 publications with ECE2 and Liver
 Ovary Antibodies  >2 publications with ECE2 and Ovary
 Embryonic Tissue Antibodies  >2 publications with ECE2 and Embryonic Tissue
 Muscle Antibodies  >2 publications with ECE2 and Muscle
 Lymph Node Antibodies  >1 publications with ECE2 and Lymph Node
 Skin Antibodies  >1 publications with ECE2 and Skin
 Blood Antibodies  >1 publications with ECE2 and Blood
 Lymph Antibodies  >1 publications with ECE2 and Lymph
 Adrenal Gland Antibodies  >1 publications with ECE2 and Adrenal Gland
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