Serum Amyloid P-Component (APCS) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]

APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.

Protein type: Chaperone; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular region; extracellular space; nucleus

Molecular Function: calcium ion binding; carbohydrate binding; complement component C1q binding; unfolded protein binding; virion binding

Biological Process: acute-phase response; cellular protein metabolic process; chaperone-mediated protein complex assembly; innate immune response; negative regulation of acute inflammatory response; negative regulation of monocyte differentiation; negative regulation of viral reproduction; negative regulation of virion penetration into host cell; protein folding